Isolated stellate cells and hepatocytes, and their cultures as in vitro models for pharmacotoxicologic research of new antifibrogenic drugs

Project Details

Description

Inhibitors of histone deacetylase are a new group of potential antifibrogenic and antitumoral drugs. Their pharmacological activity has been shown in vitro, as well as in vivo. Natural Trichostatin A is the best known compound. However, its biotransformation and toxicologic profile have not been studied yet. Recently, small amounts of structural analogues of Trichostatin A have been synthesized (Prof. Dr. D. Tourwé) in order to select the pharmacological most promising and least toxic compound. To this end, in vitro methods are preferred because of ethical, economical and scientific reasons. Moreover, the low availability of the newly synthesized molecules and their possible metabolites makes in vivo testing impossible.
AcronymFWOTM137
StatusFinished
Effective start/end date1/10/9917/07/04

Flemish discipline codes

  • Basic sciences
  • Pharmaceutical sciences

Keywords

  • toxicology
  • hepatocytes
  • in vitro study
  • histone deacetylase inhibitoren