Joint R&D 2023: Genomics for vulnerable patients with rare cardiovascular disorders

G4Heart aims to support the significant number of vulnerable patients with rare cardiovascular disorders. For this purpose, we envision deploying a platform that allows for the storage and analysis of omics data (genomic and phenotypic), the exchange of advanced analysis tools for such data, and the collaboration of researchers across the world concerned with these disorders. Importantly, our platform will enable uniting the various stakeholders to advance the scientific and technological know-how on these rare diseases –with patient involvement– while allowing commercial replication of this model. Indeed, research into diseases affecting this type of vulnerable patient is heavily hampered on one hand by the lack of access to data, largely caused by the lack of patient involvement; and on the other by the classic laboratory-based approach that does not take advantage of advances in genomics, bioinformatics and radiomics. G4Heart aims to overcome these pitfalls by introducing a disruptive way of collecting, processing and exchanging data and tools, expected to be transformational for the research on these rare diseases.