Kinetics and toxicity of protein aggregation

  • Rousseau, Frederic, (Administrative Promotor)

Project Details

Description

Objectives
1 Understanding the kinetic mechanism by which amyloids or cross-beta aggregation form, including the characterisation of the intermediates that accumulate during the aggregation process.
2 Determining the toxicity of the different aggregated species analysed in (1) to mammalian cells in culture.
3 Investigating the effect of therapeutic antibodies on the kinetics of the aggregation process, and compare this with the effect of molecular chaperones.
4 Obtain insight into the structure of the relevant eggregates using high resolution electron microscopy (in collaboration) in conjunction with in silico modelling.
AcronymFWOAL416
StatusFinished
Effective start/end date1/01/0731/12/10

Flemish discipline codes

  • Biological sciences

Keywords

  • biology