In this project, we will investigate the applicability of cfDNA to track genetic
changes throughout MM disease progression. We will also study the
applicability of circulating biomarkers (i.e. cfDNA and DNA derived from CTCs)
for epigenetic tumor profiling in MM. In a final phase, applicability of
(epi)genetic analysis using circulating biomarkers in patients with clinical
remission or at/before disease progression will be studied and correlated with
the results of Immunoglobulin-targeted NGS.