Mechanistic in vitro and in vivo study of new drug combinations in multiple myeloma.

Project Details

Description

Multiple myeloma (MM) is a plasma cell malignancy which resides in the bone marrow (BM). Here, MM cells receive signals to survive, grow and escape drug-induced cell death. Although drugs targeting these signals have significantly improved the overall survival, patients still inevitably relapse and die, underscoring the urgent need for novel targets and therapeutic approaches. In the current project, we will first test two new drug combinations which are selected based on a high likelihood of synergism between the compounds using both human MM cells and the 5T33MM murine model. In a second step, we will try to elucidate the underlying mechanisms of the potential synergistic anti-MM activity both in vitro and in vivo where the MM cells are protected by the BM microenvironment.
AcronymANI94
StatusFinished
Effective start/end date1/01/1331/12/15

Keywords

  • Blood
  • Stem Cell
  • Coagulation
  • Myeloma
  • Immunology
  • Microbiology
  • HLA
  • Hematology
  • Lymphoma
  • cancer
  • Bone Marrow Transplantation

Flemish discipline codes

  • Basic sciences
  • Biological sciences