Nanobiotics: a novel discovery pipeline for the development of antimicrobial biologicals active against extracellular bacterial targets

Project Details

Description

Antibiotic resistance is emerging as a major global threat for the continued effective treatment and prevention of infections caused by bacteria, parasites, viruses and fungi, and is currently the
second leading cause of death worldwide. Drug resistance is increasingly becoming a concern in common bacterial infections hereto regarded largely as conquered, including pneumonia, and urinary and gastrointestinal tract infections. Multidrug-resistant strains can be associated with environments with high selective pressure such as care centers and hospital settings, but have also seen an alarming rise in community-acquired infections. In view of the relentless increase in antibiotic resistance in human pathogens, efforts are needed to safeguard our future therapeutic options against infectious diseases. In addition to regulatory changes in our antibiotic use, this will have to include the development of new therapeutic compounds.
In this project, I will develop a novel discovery pipeline for the development of antimicrobial biologicals (Nanobiotics) active against extracellular bacterial targets. I will make use of, and expand the fundamental knowledge of biosynthetic, secretory and metabolic pathways operating at bacterial cell surfaces and develop an innovative immunization – panning – characterization methodology for the discovery of surface-exposed antibacterial targets and inhibitory biologicals interacting with them.

AcronymFWOTM903
StatusActive
Effective start/end date1/10/1830/09/22

Keywords

  • infections
  • nanobiotics

Flemish discipline codes

  • Microbiology not elsewhere classified