Project Details
Description
The aim of this project is to unravel the role of astrocytes in the pathogenesis of multiple sclerosis (MS).
Astrocytes in MS tissue lack beta2-adrenoreceptors. These receptors play a crucial role in the immune response of the CNS, energy metabolism and CNS perfusion, and the production of neurotrophic factors. The loss of astrocytic beta2-receptors is possibly triggered by a viral infection.
In the present research project we will:
- investigate the role of canine distemper viral infection in the loss of beta2-adrenoreceptors
- test new therapeutic interventions for MS aimed at a compensation of astrocytic beta2-receptor loss
- investigate the role of aberrant energy metabolism in axonal degeneration in MS.
Astrocytes in MS tissue lack beta2-adrenoreceptors. These receptors play a crucial role in the immune response of the CNS, energy metabolism and CNS perfusion, and the production of neurotrophic factors. The loss of astrocytic beta2-receptors is possibly triggered by a viral infection.
In the present research project we will:
- investigate the role of canine distemper viral infection in the loss of beta2-adrenoreceptors
- test new therapeutic interventions for MS aimed at a compensation of astrocytic beta2-receptor loss
- investigate the role of aberrant energy metabolism in axonal degeneration in MS.
| Acronym | OZR2038 |
|---|---|
| Status | Finished |
| Effective start/end date | 1/01/10 → 31/12/12 |
Keywords
- neurodegeneration
- multiple sclerosis
- astrocytes
- neuroprotection
Flemish discipline codes 2018-2023
- Basic sciences
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