Odysseus

  • De Keyser, Jacques (Administrative Promotor)
  • Kooijman, Ron (Co-Promotor)
  • Clinckers, Ralph, (Co-Promotor)
  • Demol, Frauke, (Collaborator)
  • Wilczak, N. (Collaborator)

Project Details

Description

The aim of this project is to unravel the role of astrocytes in the pathogenesis of multiple sclerosis (MS).

Astrocytes in MS tissue lack beta2-adrenoreceptors. These receptors play a crucial role in the immune response of the CNS, energy metabolism and CNS perfusion, and the production of neurotrophic factors. The loss of astrocytic beta2-receptors is possibly triggered by a viral infection.

In the present research project we will:
- investigate the role of canine distemper viral infection in the loss of beta2-adrenoreceptors
- test new therapeutic interventions for MS aimed at a compensation of astrocytic beta2-receptor loss
- investigate the role of aberrant energy metabolism in axonal degeneration in MS.
AcronymOZR2038
StatusFinished
Effective start/end date1/01/1031/12/12

Flemish discipline codes

  • Basic sciences

Keywords

  • neurodegeneration
  • multiple sclerosis
  • astrocytes
  • neuroprotection