Overdrachten voor het doctoraat van Frauke De Mol

Project Details

Description

Multiple sclerosis (MS) is a chronic, disabling disease of the central nervous system (CNS). Due to its chronicity and its preponderance of diagnosis in young patients, MS has a major socioeconomic impact.

Typical of MS is the development of focal lesions within the white matter, characterised by inflammation, demyelination and axonal injury. Recent evidence suggests that excitotoxicity plays an important role in damaging axons and oligodendrocyte injury leading to demyelination.

The cause of MS remains largely unknown. Our research group recently proposed an alternative hypothesis to the well known T-cell mediated model of the disease. We suggested that a loss of beta2-adrenergic receptors on astrocytes plays an important role in developing MS by affecting the activity of glutamate transporters, thereby causing excitotoxicity.

Within this project we will unravel the involvement of the glutamate transporters (in particular the cystine/glutamate antiporter) in the pathogenesis of MS and investigate the link between possible glutamate transporter dysfunction and beta2-adrenergic receptor dysfunction.

These new approaches will give us more insight in the mechanism underlying the pathogenesis of MS, which may ultimately lead to more efficient therapies for this debilitating disease.
AcronymADSI221
StatusFinished
Effective start/end date3/11/0931/08/14

Flemish discipline codes

  • Basic sciences

Keywords

  • neuroscience