Pannexin1 (Panx1) channels mediate paracrine signaling and have emerged as key players in inflammation, which is associated with a plethora of diseases. Among those is non-alcoholic steatohepatitis (NASH), being the predominant type of chronic liver disease in Western countries. This actually defines the scope of the present postdoctoral research project. The role of Panx1 channels in NASH will be studied at the transcriptional, translational and functional level using an advanced in vitro model consisting of spheroid cultures of primary human hepatocytes. This will be complemented by the testing of clinical liver samples of NASH patients. Subsequently, Panx1 expression and/or channel functionality will be experimentally suppressed in the NASH in vitro model as well as in a human- relevant mouse model of NASH, and effects will be studied on the transcriptome, lipid accumulation and inflammation. Through the combination of fundamental, translational and clinical research and by relying on in vitro and in vivo experimentation, this postdoctoral research project is considered of pharmaceutical and clinical relevance, as it may introduce a novel strategy for the treatment of NASH.
|Effective start/end date||1/10/21 → 30/09/22|
Flemish discipline codes
- Toxicology and toxinology not elsewhere classified
- Pharmacology not elsewhere classified
- Cell signalling
- Cellular communication
- Non-alcoholic steatohepatitis