This study focuses on the biochemical and psychological characterisation of receptors and binding proteins for insect peptides wich share structural and functional similarities with members of the vertebrate tachykinin (neurokinin, NK) and neuropeptide Y (NPY) families of neuropeptides . To achieve this goal, a multidisciplinary approach consisting of advanced technologies based on molecular biology, signal transduction research and radioligand binding analyses, is proposed . The major objectives of this collaborative 4-year-project are : a) a molecular biological characterisation of locust receptor-(sub)types which are members of the subfamily of NK- and NPY-receptors; b) purification and cloning of neuropeptide binding protein(s) present in the toxic secretions of the snail Conus anemone; c) identification and selection of receptor ligands; d) localisation and caracterisation of the locust's native receptors; development of sensetive and specific assays for insect neuropeptides .
|Effective start/end date||1/01/99 → 31/12/02|
Flemish discipline codes
- Biological sciences
- physiology (invertebrates)
- Endocrinology (invertebrates)