Postdoctoral Sponsorship agreement - AXA. Exosomal communication: Identifying novel targets in Multiple Myeloma (postdoctoral research topic).

Project Details

Description

Multiple Myeloma (MM) is an incurable plasma cell malignancy with an
incidence of 5 per 100,000 inhabitants, thus affecting approximately 25,000
new patients per year in the EU. The MM tumor clone develops primarily in
the bone marrow (BM) as this microenvironment is the most optimal niche for
tumor cell survival. Moreover, the BM provides protection against most types
of drug treatments, leading to MM patient relapse. Therefore there is a need
for alternative treatment strategies, targeting the BM microenvironment itself,
thereby preventing MM regrowth. In this project we wish to interfere with the
BM-MM interactions on the exosome level and examine whether exosomes
can be useful biomarkers in MM. Exosomes are 30-100nm diameter
membranous vesicles constitutively released by several cell types. They
mediate local cell-cell communication and have been shown to be elevated in
cancer. This project could ultimately lead to identification of novel biomarkers
and new therapeutic targets.
AcronymAII106
StatusFinished
Effective start/end date1/10/1430/09/16

Keywords

  • Blood
  • Stem Cell
  • Coagulation
  • Myeloma
  • Immunology
  • Microbiology
  • HLA
  • Hematology
  • Lymphoma
  • cancer
  • Bone Marrow Transplantation

Flemish discipline codes

  • Immunology
  • Oncology
  • Hematology
  • Microbiology