Prolactin signaltransduction: functional analysis of'Suppressor of cytokine signaling (SOCS)-7': characterization of the biochemical and biological properties.

Project Details

Description

The functional properties of SOCS7 are studied. SOCS7 is expressed in human leukocytes,brain cells, fibroblasts and hematopoïetic cells. SOCS7 interacts with the EGF-R, phosfolipase G gamma and the adaptor molecule NCK and Ash/Grb2.
The working mechanisms of SOCS7 will be characterized in epithelial en lymphoid cells. The subcellular localisation of SOCS7 will be identified. The proteins interacting with SOCS7 will be defined and the in vitro rol of SOCS7 will be analyzed.
AcronymOZR771
StatusFinished
Effective start/end date1/01/02 → 31/12/03

Keywords

  • gist dubbel-hybriedensysteem
  • interaction partners
  • interactiepartners
  • SOCS7
  • subcellaire expressie
  • subcellular expression
  • co-immunoprecipitatie
  • signalling
  • GST pulldown

Flemish discipline codes in use since 2023

  • Biological sciences

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