Proteïns : interactions involved in folding, function and supramolecular assemblages.

Proteins are the most important macromolecules for the functioning of the cells and molecular interactions are the central phenomena which can explain their behaviours: the tertiary structures of proteins and the dynamics of these structures depend mainly on intramolecular interactions while their quaternary structures and their associations with ligands of all sizes rest on intermolecular interactions. These ligands can be substrates, inhibitors, effectors, nucleic acids, lipid bilayers or other proteins. Unwanted alterations of these interactions can transform a normal process into an aberrant one, resulting in many types of pathologies. Alternatively, antimicrobial chemotherapy rests on a perturbation of the metabolic processes of the parasite. The present network is devoted to the most fundamental aspects of protein science in order to contribute to filling the gap mentioned above.