ProteinContour: proteome-scale unraveling of the relation between post-translational modifications, biophysical properties, interactions and sub-cellular location of proteins.

Project Details

Description

Human cells have compartments, each with different functions.
These different functions mainly arise because each compartment
contains a different set of proteins. When some proteins end up in
the wrong compartment of the cell, this can cause disease, as the
cell cannot function properly any more. Proteins themselves are
molecular machines composed of amino acids, connected to each
other via the protein backbone, a single chemical structure. Some of
these amino acids can be modified by the cell, which changes how
the protein behaves, for example the proteins it interacts with, or the
cellular compartment it prefers. In this project, we investigate i) the
modifications proteins have in different cellular compartments, ii) how
these proteins interact with each other based on their modifications,
and iii) how this affects the way these proteins behave. This way, we
hope to illuminate what makes proteins move to, or even between,
certain cellular compartments, and how that can cause disease
AcronymFWOAL1001
StatusActive
Effective start/end date1/01/2131/12/24

Keywords

  • Post translational modifications
  • biophysical characteristics of proteins
  • sub-cellular location of proteins

Flemish discipline codes

  • Bioinformatics of disease
  • Molecular biophysics
  • Proteins
  • Proteomics
  • Structural bioinformatics and computational proteomics