Role of brain angiotensin peptides in the regulation of sympathetic tone and blood pressure: interaction with glutamate, GABA and NO

This project aims to increase our understanding of the central regulation of blood pressure by correlating alterations in key brain neurotransmitters with changes in blood pressure and activity of the nervous system and by studying relevant reciprocal receptor-neurotransmitter interactions in the brain. Experiments will be done in part in anaesthetized but mainly in conscious normal rats, as well as in hypertensive animal models. In addition, we will try to elucidate the central mechanisms involved in the recently confirmed hypotensive response to renal denervation.