Project Details


During surgery, the surgeon can merely rely on visual inspection.
NLITESurgery aims to investigate novel intraoperative imaging
applications based on time-domain fluorescence lifetime imaging (tdFLI)
that will surpass the more traditional fluorescence guided surgery field
by increasing image specificity and providing new information on
(patho)physiological processes. More specifically, we propose to
conceive a unique video-rate tdFLI system that will boost the
applications of the clinically available fluorescent dye ICG, or that can be
used in combination with dedicated nanobody-based targeted
fluorescent tracers. Ultimately, this will improve surgical accuracy,
influence decision-making on a per patient basis and reduce surgicallyinduced
side effects.
To this end, a multidisciplinary consortium composed of surgeons,
medical scientists, imaging specialists, engineers, and chemists was
established. The consortium will be headed by Prof. Lahoutte and brings
together experts with international reputation in electronic engineering
of fluorescence cameras (lifetime sensing by Prof. Kuijk and Prof.
Ingelberts, ETRO, VUB and backside illumination processing by imec with
Dr. Sabuncuoglu Tezcan), fluorescent tracer development (Prof. Hernot,
ICMI, VUB; Prof. van Leeuwen, LUMC, NL) and oncologic surgery (Prof.
De Rooster, Small Animal Surgery, UGent; Prof. De Sutter, Gynaecology,
UZBrussel). The consortium will be advised by experts in precision
surgery, surgical robots, cGMP production of biologicals, sensor
development and visualization solutions.
Effective start/end date1/10/2130/09/25


  • Biopharmaceuticals
  • Image-guided interventions
  • Oncological surgery

Flemish discipline codes

  • Biopharmaceuticals