SBO project with a primary economic finality aimed at the transfer to existing companies : iPSC-based parenchymal and sinusoidal liver cell mimics for DILI and NAFLD studies (iPSC-LiMic)

van Grunsven, Leo (Administrative Promotor)

Description

iPSC-LiMic will establish a unique platform in Flanders, and one of the few in Europe, where in iPSC- derived parenchymal hepatocytes as well as sinusoidal cells (hepatic stellate cells, HSCs; liver sinusoidalendothelial cells, LSECs; and Kupffer cells, KCs) are created from human iPSC and assembled in 3D cocultures (termed 3D iPS-liver mimics), whichcan be maintained for >20 days in culture

Acronym	FWOSBO39
Status	Finished
Effective start/end date	1/10/20 → 30/09/24

Keywords

liver mimics
biomedicine

Flemish discipline codes in use since 2023

Biostatistics

4 Article

Human iPSC-derived liver co-culture spheroids to model liver fibrosis
Cools, L., Kazemzadeh Dastjerd, M., Smout, A., Merens, V., Yang, Y., Reynaert, H., Messaoudi, N., De Smet, V., Kumar, M., Verhulst, S., Verfaillie, C. & van Grunsven, L. A., 28 Jun 2024, In: Biofabrication. 16, 3, p. 1-18 18 p., 035032.
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

48 Downloads (Pure)
Osmolar Modulation Drives Reversible Cell Cycle Exit and Human Pluripotent Cell Differentiation via NF-κВ and WNT Signaling
Chui, J. S-H., Izuel-Idoype, T., Qualizza, A., de Almeida, R. P., Piessens, L., van der Veer, B. K., Vanmarcke, G., Malesa, A., Athanasouli, P., Boon, R., Vriens, J., van Grunsven, L., Koh, K. P., Verfaillie, C. M. & Lluis, F., 16 Feb 2024, In: Advanced Science. 11, 7, 21 p., 2307554.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2 Citations (Scopus)

71 Downloads (Pure)
A fully defined matrix to support a pluripotent stem cell derived multi-cell-liver steatohepatitis and fibrosis model
Kumar, M., Toprakhisar, B., Van Haele, M., Antoranz, A., Boon, R., Chesnais, F., De Smedt, J., Tricot, T., Idoype, T. I., Canella, M., Tilliole, P., De Boeck, J., Bajaj, M., Ranga, A., Bosisio, F. M., Roskams, T., van Grunsven, L. A. & Verfaillie, C. M., Sep 2021, In: Biomaterials. 276, 121006.
Research output: Contribution to journal › Article › peer-review

Open Access
21 Citations (Scopus)

SBO project with a primary economic finality aimed at the transfer to existing companies : iPSC-based parenchymal and sinusoidal liver cell mimics for DILI and NAFLD studies (iPSC-LiMic)

Project Details

Description

Keywords

Flemish discipline codes in use since 2023

Fingerprint

Human iPSC-derived liver co-culture spheroids to model liver fibrosis

Osmolar Modulation Drives Reversible Cell Cycle Exit and Human Pluripotent Cell Differentiation via NF-κВ and WNT Signaling

A fully defined matrix to support a pluripotent stem cell derived multi-cell-liver steatohepatitis and fibrosis model

SBO project with a primary economic finality aimed at the transfer to existing companies : iPSC-based parenchymal and sinusoidal liver cell mimics for DILI and NAFLD studies (iPSC-LiMic)

Project Details

Description

Keywords

Flemish discipline codes in use since 2023

Fingerprint

Research output

Human iPSC-derived liver co-culture spheroids to model liver fibrosis

Osmolar Modulation Drives Reversible Cell Cycle Exit and Human Pluripotent Cell Differentiation via NF-κВ and WNT Signaling

A fully defined matrix to support a pluripotent stem cell derived multi-cell-liver steatohepatitis and fibrosis model