Strategic Research Programme: Molecular Imaging and targeting of macrophages in Inflammation (ITARMI)

Research output

Research output per year 2016 2017 2018 2019 2021 2021

• 39 Article

Research output per year

Research output per year

Search results

• 2021

  Development and Characterization of Nanobodies Targeting the Kupffer Cell

  Zheng, F., Zhou, J., Ouyang, Z., Zhang, J., Wang, X., Muyldermans, S., Van Ginderachter, J., Devoogdt, N., Wen, Y., Schoonooghe, S. & Raes, G., 22 Feb 2021, In: Frontiers in Immunology. 12, 12 p., 641819.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Single-Domain Antibodies 100%
  • Kupffer Cells 81%
  • Kupffer cell receptor 33%
  • Epitopes 28%
  • New World Camelids 12%
  7 Citations (Scopus)

  67 Downloads (Pure)

• Formatting and gene-based delivery of a human PD-L1 single domain antibody for immune checkpoint blockade

  Awad, R. M., Lecocq, Q., Zeven, K., Ertveldt, T., De Beck, L., Ceuppens, H., Broos, K., De Vlaeminck, Y., Goyvaerts, C., Verdonck, M., Raes, G., Van Parys, A., Cauwels, A., Keyaerts, M., Devoogdt, N. & Breckpot, K., 10 Sep 2021, In: Molecular Therapy: Methods & Clinical Development. 22, 9, p. 172-182 11 p., 10.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Single-Domain Antibodies 100%
  • avelumab 58%
  • T-Cell Antigen Receptor 34%
  • Melanoma 28%
  • Genes 27%
  12 Citations (Scopus)

  108 Downloads (Pure)

• IL1β Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D

  Kiss, M., Vande Walle, L., Saavedra, P. H. V., Lebegge, E., Van Damme, H., Murgaski, A., Qian, J., Ehling, M., Pretto, S., Bolli, E., Keirsse, J., Bardet, P. M. R., Arnouk, S. M., Elkrim, Y., Schmoetten, M., Brughmans, J., Debraekeleer, A., Fossoul, A., Boon, L., Raes, G. & 8 others, van Loo, G., Lambrechts, D., Mazzone, M., Beschin, A., Wullaert, A., Lamkanfi, M., Van Ginderachter, J. A. & Laoui, D., Mar 2021, In: Cancer Immunology Research. 9, 3, p. 309-323 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Inflammasomes 100%
  • Tumor Microenvironment 86%
  • Neoplasms 26%
  • T-Lymphocytes 25%
  • Macrophages 21%
  50 Citations (Scopus)

  174 Downloads (Pure)

• Lyophilization of NOTA-sdAbs: First step towards a cold diagnostic kit for 68Ga-labeling

  Baudhuin, H., Van Bockstal, P-J., De Beer, T., Vaneycken, I., Bridoux, J., Raes, G., Caveliers, V., Keyaerts, M., Devoogdt, N., Lahoutte, T. & Xavier, C., Sep 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 166, p. 194-204 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 1,4,7-triazacyclononane-N,N',N''-triacetic acid 100%
  • Single-Domain Antibodies 86%
  • Immunoglobulin Fragments 74%
  • Freeze Drying 73%
  • Cold Temperature 51%
  4 Citations (Scopus)

  223 Downloads (Pure)

• Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation

  Virga, F., Cappellesso, F., Stijlemans, B., Henze, A-T., Trotta, R., Van Audenaerde, J., Mirchandani, A. S., Sanchez-Garcia, M. A., Vandewalle, J., Orso, F., Riera-Domingo, C., Griffa, A., Ivan, C., Smits, E., Laoui, D., Martelli, F., Langouche, L., Van den Berghe, G., Feron, O., Ghesquière, B. & 8 others, Prenen, H., Libert, C., Walmsley, S. R., Corbet, C., Van Ginderachter, J. A., Ivan, M., Taverna, D. & Mazzone, M., 7 May 2021, In: Science Advances. 7, 19, eabf0466.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • MicroRNAs 100%
  • Macrophages 83%
  • Inflammation 69%
  • Monocytes 49%
  • Sepsis 47%
  35 Citations (Scopus)

• Monocytic myeloid-derived suppressor cells home to tumor-draining lymph nodes via CCR2 and locally modulate the immune response

  Lahmar, Q., Schouppe, E., Morias, Y., Van Overmeire, E., De Baetselier, P., Movahedi, K., Laoui, D., Sarukhan, A. & Van Ginderachter, J. A., Apr 2021, In: Cellular Immunology. 362, 8 p., 104296.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Myeloid-Derived Suppressor Cells 100%
  • Lymph Nodes 53%
  • Tumor Microenvironment 31%
  • Neoplasms 24%
  • T-Lymphocytes 18%
  8 Citations (Scopus)

  31 Downloads (Pure)

• Myeloid tumor necrosis factor and heme oxygenase-1 regulate the progression of colorectal liver metastases during hepatic ischemia-reperfusion

  Germanova, D., Keirsse, J., Köhler, A., Hastir, J-F., Demetter, P., Delbauve, S., Elkrim, Y., Verset, L., Larbanoix, L., Preyat, N., Laurent, S., Nedospasov, S., Donckier, V., Van Ginderachter, J. A. & Flamand, V., 1 Mar 2021, In: International Journal of Cancer. 148, 5, p. 1276-1288 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Heme Oxygenase-1 100%
  • Reperfusion 74%
  • Ischemia 64%
  • Tumor Necrosis Factor-alpha 60%
  • Neoplasm Metastasis 52%
  9 Citations (Scopus)

• Phase I trial of 131I-GMIB-Anti-HER2-VHH1, a new promising candidate for HER2-targeted radionuclide therapy in breast cancer patients

  D'Huyvetter, M., De Vos, J., Caveliers, V., Vaneycken, I., Heemskerk, J., Duhoux, F. P., Fontaine, C., Vanhoeij, M., Windhorst, A. D., van der Aa, F., Hendrikse, N. H., Eersels, J. L. E., Everaert, H., Gykiere, P., Devoogdt, N., Raes, G., Lahoutte, T. & Keyaerts, M., 1 Aug 2021, In: Journal of Nuclear Medicine. 62, 8, p. 1097-1105 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Radioisotopes 100%
  • Breast Neoplasms 62%
  • Kidney 52%
  • Single Photon Emission Computed Tomography Computed Tomography 50%
  • N-succinimidyl 4-guanidinomethyl-3-iodobenzoate 42%
  77 Citations (Scopus)

• Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

  Pombo Antunes, A. R., Scheyltjens, I., Lodi, F., Messiaen, J., Antoranz, A., Duerinck, J., Kancheva, D., Martens, L., De Vlaminck, K., Van Hove, H., Kjølner Hansen, S. S., Bosisio, F. M., Van der Borght, K., De Vleeschouwer, S., Sciot, R., Bouwens, L., Verfaillie, M., Vandamme, N., Vandenbroucke, R. E., De Wever, O. & 8 others, Saeys, Y., Guilliams, M., Gysemans, C., Neyns, B., De Smet, F., Lambrechts, D., Van Ginderachter, J. A. & Movahedi, K., Apr 2021, In: Nature Neuroscience. 24, 4, p. 595-610 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Myeloid Cells 100%
  • Glioblastoma 96%
  • Macrophages 68%
  • Microglia 33%
  • Neoplasms 31%
  350 Citations (Scopus)

  1094 Downloads (Pure)

• Targeted Repolarization of Tumor-Associated Macrophages via Imidazoquinoline-Linked Nanobodies

  Bolli, E., Scherger, M., Arnouk, S., Pombo Antunes, A. R., Straßburger, D., Urschbach, M., Stickdorn, J., De Vlaminck, K., Movahedi, K., Räder, H. J., Hernot, S., Besenius, P., Van Ginderachter, J. & Nuhn, L., 19 May 2021, In: Advanced Science. 8, 10, 12 p., 2004574.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Macrophages 100%
  • Single-Domain Antibodies 88%
  • macrophages 85%
  • Tumors 60%
  • tumors 56%
  46 Citations (Scopus)

  274 Downloads (Pure)

• Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy

  Van Damme, H., Dombrecht, B., Kiss, M., Roose, H., Allen, E., Van Overmeire, E., Kancheva, D., Martens, L., Murgaski, A., Bardet, P., Blancke, G., Jans, M., Bolli, E., Martins, M. S., Elkrim, Y., Dooley, J., Boon, L., Schwarze, J. K., Tacke, F., Movahedi, K. & 9 others, Vandamme, N., Neyns, B., Ocak, S., Scheyltjens, I., Vereecke, L., Nana, F. A., Merchiers, P., Laoui, D. & Van Ginderachter, J. A., Feb 2021, In: Journal for immunotherapy of cancer. 9, 2, 16 p., e001749.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Programmed Cell Death 1 Receptor 100%
  • Regulatory T-Lymphocytes 69%
  • Antibody-Dependent Cell Cytotoxicity 67%
  • Immunity 56%
  • Single-Domain Antibodies 29%
  115 Citations (Scopus)

  57 Downloads (Pure)
• 2020

  Identifying the variables that drive tamoxifen-independent CreERT2 recombination: implications for microglial fate mapping and gene deletions.

  Van Hove, H., Pombo Antunes, A. R., De Vlaminck, K., Scheyltjens, I., Van Ginderachter, J. & Movahedi, K., 3 Mar 2020, In: European Journal of Immunology. 50, 3, p. 459-463 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Gene Deletion 100%
  • Tamoxifen 97%
  • Genetic Recombination 88%
  • Macrophages 64%
  • Cre recombinase 62%
  36 Citations (Scopus)

• Transient Multivalent Nanobody Targeting to CD206-Expressing Cells via PH-Degradable Nanogels.

  Scherger, M., Bolli, E., Pombo Antunes, A. R., Arnouk, S., Stickdorn, J., Van Driessche, A., Schild, H., Grabbe, S., De Geest, B., Van Ginderachter, J. & Nuhn, L., 1 Oct 2020, In: Cells. 9, 10, 14 p., 2222.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nanogels 100%
  • Single-Domain Antibodies 94%
  • Ketal 77%
  • Polymer Chain 54%
  • polyethylene glycol polyethyleneimine nanogel 41%
  8 Citations (Scopus)

• Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies

  Pombo Antunes, A. R., Scheyltjens, I., Duerinck, J., Neyns, B., Movahedi, K. & Van Ginderachter, J. A., 4 Feb 2020, In: eLife. 9, 52176.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Refractory 100%
  • Glioblastoma 95%
  • Neoplasms 31%
  • Reaction Yield 19%
  • Immunosuppressive Agents 17%
  184 Citations (Scopus)

• Validation of miR-20a as a Tumor Suppressor Gene in Liver Carcinoma Using Hepatocyte-Specific Hyperactive piggyBac Transposons

  Tipanee, J., Di Matteo, M., Tulalamba, W., Samara-Kuko, E., Keirsse, J., Van Ginderachter, J. A., Chuah, M. K. & VandenDriessche, T., 6 Mar 2020, In: Molecular Therapy Nucleic Acids. 19, p. 1309-1329 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • MicroRNA 100%
  • Tumor Suppressor Genes 80%
  • Hepatocytes 68%
  • Hepatocellular Carcinoma 65%
  • Carcinoma 53%
  9 Citations (Scopus)
• 2019

  A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

  Van Hove, H., Martens, L., Scheyltjens, I., De Vlaminck, K., Pombo Antunes, A. R., De Prijck, S., Vandamme, N., De Schepper, S., Van Isterdael, G., Scott, C. L., Aerts, J., Berx, G., Boeckxstaens, G. E., Vandenbroucke, R. E., Vereecke, L., Moechars, D., Guilliams, M., Van Ginderachter, J., Saeys, Y. & Movahedi, K., 6 May 2019, In: Nature Neuroscience. 22, 6, p. 1021-1035 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Atlases 100%
  • Macrophages 65%
  • Choroid Plexus 46%
  • Brain 45%
  • RNA Sequence Analysis 41%
  594 Citations (Scopus)

• Clinical Translation of [68Ga]Ga-NOTA-anti-MMR-sdAb for PET/CT Imaging of Protumorigenic Macrophages

  Xavier, C., Blykers, A., Laoui, D., Bolli, E., Vaneycken, I., Bridoux, J., Baudhuin, H., Raes, G., Everaert, H., Movahedi, K., Van Ginderachter, J. A., Devoogdt, N., Caveliers, V., Lahoutte, T. & Keyaerts, M., 1 Oct 2019, In: Molecular Imaging and Biology. 21, 5, p. 898-906 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 1,4,7-triazacyclononane-N,N',N''-triacetic acid 100%
  • Single-Domain Antibodies 86%
  • Immunoglobulin Fragments 74%
  • Positron Emission Tomography Computed Tomography 63%
  • Macrophages 40%
  77 Citations (Scopus)

  292 Downloads (Pure)

• High Salt Inhibits Tumor Growth by Enhancing Anti-tumor Immunity

  Willebrand, R., Hamad, I., Van Zeebroeck, L., Kiss, M., Bruderek, K., Geuzens, A., Swinnen, D., Fernandes Côrte-Real, B., Markó, L., Lebegge, E., Laoui, D., Kemna, J., Kammertoens, T., Brandau, S., Van Ginderachter, J. & Kleinewietfeld, M., 4 Jun 2019, In: Frontiers in Immunology. 10, JUN, 1141.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Salts 100%
  • Immunity 92%
  • Myeloid-Derived Suppressor Cells 60%
  • Growth 57%
  • Neoplasms 36%
  38 Citations (Scopus)

• Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition

  Newton, J. M., Hanoteau, A., Liu, H-C., Gaspero, A., Parikh, F., Gartrell-Corrado, R. D., Hart, T. D., Laoui, D., Van Ginderachter, J. A., Dharmaraj, N., Spanos, W. C., Saenger, Y., Young, S. & Sikora, A. G., 13 Aug 2019, In: Journal for immunotherapy of cancer. 7, 1, 21 p., 216.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Radiotherapy 100%
  • Tumor Microenvironment 81%
  • N(6)-(1-iminoethyl)lysine 69%
  • CTLA-4 Antigen 54%
  • Neoplasms 46%
  61 Citations (Scopus)

• Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer

  Bieniasz-Krzywiec, P., Martín-Pérez, R., Ehling, M., García-Caballero, M., Pinioti, S., Pretto, S., Kroes, R., Aldeni, C., Di Matteo, M., Prenen, H., Tribulatti, M. V., Campetella, O., Smeets, A., Noel, A., Floris, G., Van Ginderachter, J. A. & Mazzone, M., 5 Nov 2019, In: Cell Metabolism. 30, 5, p. 917-936 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lymphangiogenesis 100%
  • Macrophages 51%
  • Breast Neoplasms 46%
  • Galectins 33%
  • Endothelial Cells 27%
  163 Citations (Scopus)

• Single-domain antibody fusion proteins can target and shuttle functional proteins into macrophage mannose receptor expressing macrophages

  De Vlaeminck, Y., Lecocq, Q., Giron, P., Geeraerts, X., Schoonooghe, S., Movahedi, K., Massa, S., Bolli, E., Goyvaerts, C., Van Ginderachter, J. & Breckpot, K., 10 Apr 2019, In: Journal of Controlled Release. 299, 2, p. 107-120 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Single-Domain Antibodies 100%
  • mannose receptor 96%
  • Mannose 73%
  • Macrophages 47%
  • Protein 27%
  16 Citations (Scopus)

  366 Downloads (Pure)

• Stromal-targeting radioimmunotherapy mitigates the progression of therapy-resistant tumors

  Bolli, E., D'Huyvetter, M., Murgaski, A., Berus, D., Stangé, G., Clappaert, E. J., Arnouk, S., Pombo Antunes, A. R., Krasniqi, A., Lahoutte, T., Gonçalves, A., Vuylsteke, M., Raes, G., Devoogdt, N., Movahedi, K. & Van Ginderachter, J. A., 28 Nov 2019, In: Journal of Controlled Release. 314, p. 1-11 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Radioimmunotherapy 100%
  • Mannose 78%
  • mannose receptor 51%
  • Single-Domain Antibodies 44%
  • Macrophages 37%
  24 Citations (Scopus)

• Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy

  Hanoteau, A., Newton, J. M., Krupar, R., Huang, C., Liu, H-C., Gaspero, A., Gartrell, R. D., Saenger, Y. M., Hart, T. D., Santegoets, S. J., Laoui, D., Spanos, C., Parikh, F., Jayaraman, P., Zhang, B., Van der Burg, S. H., Van Ginderachter, J. A., Melief, C. J. M. & Sikora, A. G., 15 Jan 2019, In: Journal for immunotherapy of cancer. 7, 1, 19 p., 10.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chemoradiotherapy 100%
  • Tumor Microenvironment 97%
  • N(6)-(1-iminoethyl)lysine 44%
  • Neoplasms 19%
  • Squamous Cell Carcinoma of Head and Neck 18%
  73 Citations (Scopus)
• 2018

  Neuropilin-1 upregulation elicits adaptive resistance to oncogene-targeted therapies

  Rizzolio, S., Cagnoni, G., Battistini, C., Bonelli, S., Isella, C., Van Ginderachter, J. A., Bernards, R., Di Nicolantonio, F., Giordano, S. & Tamagnone, L., 31 Aug 2018, In: Journal of Clinical Investigation. 128, 9, p. 3976-3990 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuropilin-1 100%
  • Oncogenes 64%
  • Up-Regulation 48%
  • Neoplasms 14%
  • Therapeutics 11%
  53 Citations (Scopus)

• Noninvasive imaging of the PD-1:PD-L1 immune checkpoint: Embracing nuclear medicine for the benefit of personalized immunotherapy: Embracing nuclear medicine for the benefit of personalized immunotherapy

  Broos, K., Lecocq, Q., Raes, G., Devoogdt, N., Keyaerts, M. & Breckpot, K., 7 Jun 2018, In: Theranostics. 8, 13, p. 3559-3570 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Programmed Cell Death 1 Receptor 100%
  • Molecular Imaging 82%
  • Nuclear Medicine 80%
  • Immunotherapy 61%
  • Ligands 49%
  94 Citations (Scopus)

  238 Downloads (Pure)

• Novel half-life extended anti-MIF nanobodies protect against endotoxic shock

  Sparkes, A., De Baetselier, P., Brys, L., Cabrito, I., Sterckx, Y. G-J., Schoonooghe, S., Muyldermans, S., Raes, G., Bucala, R., Vanlandschoot, P., Van Ginderachter, J. A. & Stijlemans, B., Jun 2018, In: The FASEB Journal. 32, 6, p. 3411-3422 12 p.

  Research output: Contribution to journal › Article › peer-review

  File

  • Single-Domain Antibodies 100%
  • Septic Shock 69%
  • Reaction Half Life 64%
  • Half-Life 59%
  • Glucocorticoid 43%
  32 Citations (Scopus)

  40 Downloads (Pure)

• Same-day imaging using small proteins: Clinical experience and translational prospects in oncology

  Krasniqi, A., D'Huyvetter, M., Devoogdt, N., Frejd, F. Y., Sorensen, J., Keyaerts, M. & Tolmachev, V., Jun 2018, In: Journal of Nuclear Medicine. 59, 6, p. 885-891 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radionuclide Imaging 100%
  • Immunoglobulins 91%
  • Proteins 76%
  • Injections 59%
  • Therapeutics 33%
  107 Citations (Scopus)

  70 Downloads (Pure)

• Targeting Protumoral Tumor-Associated Macrophages with Nanobody-Functionalized Nanogels through Strain Promoted Azide Alkyne Cycloaddition Ligation

  Nuhn, L., Boli, E., Massa, S., Vandenberghe, I., Movahedi, K., Devreese, B., Van Ginderachter, J. & De Geest, B. G., 18 Jul 2018, In: Bioconjugate Chemistry. 29, 7, p. 2394–2405 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Cycloaddition 100%
  • Macrophages 83%
  • Cycloaddition Reaction 82%
  • Alkynes 80%
  • Nanogels 78%
  55 Citations (Scopus)

• The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages

  Scott, C. L., T'Jonck, W., Martens, L., Todorov, H., Sichien, D., Soen, B., Bonnardel, J., De Prijck, S., Vandamme, N., Cannoodt, R., Saelens, W., Vanneste, B., Toussaint, W., De Bleser, P., Takahashi, N., Vandenabeele, P., Henri, S., Pridans, C., Hume, D. A., Lambrecht, B. N. & 8 others, De Baetselier, P., Milling, S. W. F., Van Ginderachter, J. A., Malissen, B., Berx, G., Beschin, A., Saeys, Y. & Guilliams, M., 21 Aug 2018, In: IMMUNITY. 49, 2, p. 312-325.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transcription Factors 100%
  • Macrophages 93%
  • Kupffer Cells 71%
  • Population 17%
  • Epithelial-Mesenchymal Transition 15%
  173 Citations (Scopus)
• 2017

  CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus

  Farro, G., Stakenborg, M., Gomez-Pinilla, P. J., Labeeuw, E., Goverse, G., Giovangiulio, M. D., Stakenborg, N., Meroni, E., D'Errico, F., Elkrim, Y., Laoui, D., Lisowski, Z. M., Sauter, K. A., Hume, D. A., Van Ginderachter, J. A., Boeckxstaens, G. E. & Matteoli, G., Dec 2017, In: Gut. 66, 12, p. 2098-2109 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Ileus 100%
  • Monocytes 59%
  • Macrophages 58%
  • Gastrointestinal Transit 50%
  • Inflammation 49%
  73 Citations (Scopus)

• Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner

  Vandereyken, M., Jacques, S., Van Overmeire, E., Amand, M., Rocks, N., Delierneux, C., Singh, P., Singh, M., Ghuysen, C., Wathieu, C., Zurashvili, T., Sounni, N. E., Moutschen, M., Gilles, C., Oury, C., Cataldo, D., Van Ginderachter, J. A. & Rahmouni, S., 2017, In: PLoS ONE. 12, 10, 23 p., e0185786.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lewis Lung Carcinoma 100%
  • Macrophages 77%
  • Neoplasm Metastasis 68%
  • Lung 59%
  • Neoplasms 35%
  15 Citations (Scopus)

• Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis.

  Zheng, F., Sparkes, A., De Baetselier, P., Schoonooghe, S., Stijlemans, B. A., Muyldermans, S., Flamand, V., Van Ginderachter, J., Devoogdt, N., Raes, G. & Beschin, A., Feb 2017, In: Molecular Imaging and Biology. 19, 1, p. 49-58 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Single-Domain Antibodies 100%
  • Kupffer Cells 81%
  • Molecular Imaging 79%
  • Liver 34%
  • Concanavalin A 18%
  26 Citations (Scopus)

• Novel insights in the regulation and function of macrophages in the tumor microenvironment

  Bolli, E., Movahedi, K., Laoui, D. & Van Ginderachter, J. A., Jan 2017, In: Current Opinion in Oncology. 29, 1, p. 55-61 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Tumor Microenvironment 100%
  • Macrophages 67%
  • Neoplasms 31%
  • Neoplasm Metastasis 9%
  • Macrophage Activation 9%
  53 Citations (Scopus)

• Reprint of: The non-mammalian MIF superfamily

  Sparkes, A., De Baetselier, P., Roelants, K., De Trez, C., Magez, S., Van Ginderachter, J. A., Raes, G., Bucala, R. & Stijlemans, B., Jun 2017, In: Immunobiology. 222, 6, p. 858-867 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Mammals 100%
  • Macrophage Migration-Inhibitory Factors 77%
  • Mollusca 73%
  • Arthropods 72%
  • Helminths 68%
  10 Citations (Scopus)

• The non-mammalian MIF superfamily

  Sparkes, A., De Baetselier, P., Roelants, K., De Trez, C., Magez, S., Van Ginderachter, J. A., Raes, G., Bucala, R. & Stijlemans, B., 1 Mar 2017, In: Immunobiology. 222, 3, p. 473-482 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Mammals 100%
  • Macrophage Migration-Inhibitory Factors 77%
  • Mollusca 73%
  • Arthropods 72%
  • Helminths 68%
  43 Citations (Scopus)
• 2016

  Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours

  Filtjens, J., Keirsse, J., Van Ammel, E., Taveirne, S., Van Acker, A., Kerre, T., Taghon, T., Vandekerckhove, B., Plum, J., Van Ginderachter, J. A. & Leclercq, G., 29 Jul 2016, In: Scientific Reports - Nature. 6, p. 30564

  Research output: Contribution to journal › Article › peer-review

  • Natural Killer Cells 100%
  • Major Histocompatibility Complex 87%
  • Skin 59%
  • Lung 57%
  • Liver 55%
  7 Citations (Scopus)

• M-CSF and GM-CSF receptor signaling differentially regulate monocyte maturation and macrophage polarization in the tumor microenvironment

  Van Overmeire, E., Stijlemans, B., Heymann, F., Keirsse, J., Morias, Y., Elkrim, Y., Brys, L., Abels, C., Lahmar, Q., Ergen, C., Vereecke, L., Tacke, F., De Baetselier, P., Van Ginderachter, J. A. & Laoui, D., 1 Jan 2016, In: Cancer Research. 76, 1, p. 35-42 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Colony-Stimulating Factor Receptors 100%
  • Granulocyte-Macrophage Colony-Stimulating Factor 68%
  • Tumor Microenvironment 68%
  • Monocytes 54%
  • Macrophages 45%
  181 Citations (Scopus)

• MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis

  Stijlemans, B., Brys, L., Korf, H., Bieniasz-Krzywiec, P., Sparkes, A., Vansintjan, L., Leng, L., Vanbekbergen, N., Mazzone, M., Caljon, G., Van Den Abbeele, J., Odongo, S., De Trez, C., Magez, S., Van Ginderachter, J. A., Beschin, A., Bucala, R. & De Baetselier, P., Sep 2016, In: PLoS Pathogens. 12, 9, p. e1005862

  Research output: Contribution to journal › Article › peer-review

  • Hemodilution 100%
  • trypanosomiasis 98%
  • anemia 84%
  • macrophages 69%
  • Anemia 65%
  23 Citations (Scopus)

• The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity

  Laoui, D., Keirsse, J., Morias, Y., Van Overmeire, E., Geeraerts, X., Elkrim, Y., Kiss, M., Bolli, E., Lahmar, Q., Sichien, D., Serneels, J., Scott, C. L., Boon, L., De Baetselier, P., Mazzone, M., Guilliams, M. & Van Ginderachter, J. A., 23 Dec 2016, In: Nature Communications. 7, p. 13720

  Research output: Contribution to journal › Article › peer-review

  • harbors 100%
  • immunity 91%
  • Tumor Microenvironment 81%
  • tumors 75%
  • Dendritic Cells 70%
  211 Citations (Scopus)