Structural basis of plasmid addiction and programmed cell death in bacteria

Project Details


The structure-functrion dogma states that a functional protein is characterized by a well-defined three-dimensional structure. There exists, however, a class of proteins that is intrinsically disordered in its native, functional state. The C-terminal domain of CcdA is such a protein. We recently determined the mechanism of action of CcdA as a rescuer for CcdB-poisoned gyrase. In this project, we further analyze the mopde of action of CcdA and its interaction with ccdB by a combination of X-ray crystallography, biophysics and solution NMR.
Effective start/end date1/10/0830/09/09


  • Applied Biology

Flemish discipline codes in use since 2023

  • Biological sciences


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