The aims of the study : 1) To investigate the role for the transcription factor IRF-1 in in vitro cytokine-induced expression of iNOS and MHC class I mRNAs in pancreatic beta-cells . 2) To test whether absence of IRF-1 expression prevents in vitro cytokine-induced apoptosis in pancreatic beta-cells . 3) To investigate the role for beta-cell IRF-1 expression in mouse islet allograft rejection and autoimmune diabetes recurrence .
|Effective start/end date||1/01/99 → 31/12/02|
Flemish discipline codes
- Basic sciences