Studies on the role of interferon regulatory factor-1 (IRF-1) in immune-mediated pancreatic beta cell destruction

  • Eizirik, Decio, (Administrative Promotor)

Project Details


The aims of the study : 1) To investigate the role for the transcription factor IRF-1 in in vitro cytokine-induced expression of iNOS and MHC class I mRNAs in pancreatic beta-cells . 2) To test whether absence of IRF-1 expression prevents in vitro cytokine-induced apoptosis in pancreatic beta-cells . 3) To investigate the role for beta-cell IRF-1 expression in mouse islet allograft rejection and autoimmune diabetes recurrence .
Effective start/end date1/01/9931/12/02


  • transplantation
  • auto-immunity
  • Diabetes

Flemish discipline codes

  • Basic sciences