Multiple Myeloma (M M) is a malianancy of the Bcell lineage, characterised by-the-proliferation of maliqnant plasma cells in the bone marrow (BM), secreting a monoclonal immunoalobulin (Ia). Although the predominant cell type in M M is the Plasma cell, aenetic alterations contributing to the neoplastic transformation may take place in a more immature B cell of which the real identity remalns unclear. An important phenomenon in the growth regulation of myeloma concerns functional interactions between tumor cells, or their putative precursors, and the BM environment. Various lymphokines, particularly IL-6, are involved in this growth control and their action may _be supported by adhesive mechanisms. Several major aenetic alterations and an impaired immunosurveillance seem to be associated with the progression ofM M. The collaborating teams of this Proposal have been at the edge of some of these particular aspects. They have been using different approaches to unravel these aspects, hereby developping a proper expertise in the field of myeloma research. The aim of this project is to combine the experience of the different groups and to further elucidate the immuno-biology of multiple myeloma in a concerted way. This will lead, not only to the development of new diagnostic and therapeutic strategies, but also shed liqht on the normal physiology of the humoral response and (pre) malianant events.
|Effective start/end date||1/01/95 → 31/12/97|
Flemish discipline codes
- Basic sciences