It has been described that the exchangeable sodium, a sensitive indicator for the total body sodium, is increased with 10 % in diabetic patients. Diabetic patients have also an impaired sodium excretion in response head-out water immersion, saline infusion or high salt diet. The reason for these disturbances remains nuclear. On the other side, renal dopamine is known to increase sodium excretion via interaction with tubular D 1 receptors. The aim of our project is to study the renal dopaminergic system in basal and dynamic conditions (i.e. low dose- dopamine infusions, saline infusions) in type 1 and type 2 diabetes patients as a disturbance of the renal dopaminergic system be implicated in the increased sodium retention present in diabetic patients.
|Effective start/end date||1/01/94 → 31/12/97|
Flemish discipline codes
- Basic sciences