The involvement of neuroinflammation and oxidative stress on alpha-synuclein aggregation and intercellular pathology spread in Parkinson's disease.

Project Details

Description

This project aims to validate neuroprotective compounds that are capable of preventing a-syn aggregation in vivo, by interference of inflammation and the NADPH oxidase related oxidative stress. Furthermore, we will investigate whether these mechanisms are involved in the spread of a-syn pathology. Two questions will be examined:
1) What is the relationship between oxidative stress, inflammation, and a-syn aggregation?
2) Can modulation of inflammation and oxidative stress prevent the spread of PD pathology? Is this effect also obtained by inhibiting the cell-to-cell transmission of a-syn oligomers?
AcronymFWOTM592
StatusFinished
Effective start/end date1/10/1130/09/15

Keywords

  • Aminoacids
  • Parkinsons Disease
  • Neuro-Transmitters
  • Neuropharmacology
  • clinical pharmacy
  • Stroke
  • Receptors
  • Rat Models
  • Neurochemistry
  • Pharmacokinetics
  • Microdialysis
  • neuroscience
  • Drug Research
  • Bioanalysis
  • Epilepsy
  • seamless care
  • Monoamines
  • Neurosciences
  • Liquid Chromatography
  • pharmaceutical care
  • Electrochemical Detection

Flemish discipline codes

  • (Bio)chemical engineering
  • Basic sciences
  • Health sciences
  • Pharmaceutical sciences