The role of IGF-1 in Multiple Myeloma tumor progression: effects on cell cycle and UPR response.

Project Details


Multiple myeloma (MM) is an incurable plasma cell cancer, whereby normal cell cycle controls are lost, giving the cells the phenotype of "cycling" plasma cells. MM cells reside within the bone marrow (BM), where they interact with the extracellular matrix and stromal components through adhesion molecules and cytokines (IL-6 and IGF-1) to receive necessary growth and survival signals. In this project we will investigate first the effects of IGF-1 on the cell cycle. We will investigate if IGF-1 activates new proteins or that it changes the activation of already active proteins. We will also consider if the contacts with BM stromal cells, which have a protective effect on MM cells, induce the same effects.
In a second part we will study the effects of IGF-1 on the "unfolded protein response". These "UPR" maintain the equilibrium between the rhythm of creating proteins, ER gets a stress signal that leads to the activation of UPR. This can either restore the equilibrium by sending a signal to survive or it fails what will lead to an apoptosis signal. Since the UPR, has both pro and anti-apoptotic pathways, it is unclear whether it plays a role in drug resistance and / or growth stimulation. In this project we will examine the UPR constitutively present in MM cells and the effect of IGF-1, particularly in Deport-survival away from UPR.
Effective start/end date1/01/1031/12/10

Flemish discipline codes

  • Basic sciences
  • Biological sciences


  • Stem Cell
  • Blood
  • Coagulation
  • Myeloma
  • Immunology
  • Microbiology
  • HLA
  • Hematology
  • Lymphoma
  • cancer
  • Bone Marrow Transplantation