The role of IGF-I as a survival factor in the immuun system and (prostate) cancer

Project Details

Description

The regulation and function of the founder member of the Tec kinase family "Tec" is less well understood than that of other members including Btk, Bmx and ltk. Unlike other members of the family which are mainly expressed in the hematopoietic system, Tec and Bmx are more broadly expressed (Gomez-Rodriguez et al. 2007). Hence, Tec kinase could be key to tissue homeostasis via modulation of cell survival and proliferation in normal tissues and tumor cells.
The purpose of the proposed research is to assess the role of the founder member of the Tec kinase family (Tec) in the regulation of proliferation and apoptosis.
Since increased expression of Tec kinase has been observed in liver cancer cells (Mano et al. 1990) and prostate cancer cells (unpublished observation), it is possible that Tec plays a role in progression of cancer. Therefore, we will also address the function of Tec kinase in prostate cancer cells.
AcronymOZR2004
StatusFinished
Effective start/end date1/10/0931/03/10

Flemish discipline codes

  • Basic sciences
  • Biological sciences

Keywords

  • Pituitary Tumors
  • Gene Regulation
  • IGF-1
  • Hypophyse
  • Prolactin
  • PRL-R signalling pathways
  • In Situ Hybridization
  • Lymphohemopoietic System
  • Dopamine
  • Endocrinology
  • PRL isoforms
  • PRL gene regulation
  • termination of signalling
  • CIS and SOCS molecules
  • PRL-R pathways
  • PRL
  • Growth Hormone