The role of NK (Natural Killer) Cell Activation Genes in the Cytotoxicity Against Colon Caricinoma Cells.

Project Details


Objectives : In this project we want to determine which genes are involved in hepatic NK cell activation . This goal can be achieved by using the new method of differential display reverse transcriptase polymerase chain reaction (DD.RT.PCR)(15). We wan tot apply this method to LD and HD pit cells and compare their gene exprssion patterns with spleen NK cells, both in controls and IL-2 treated cells . The purpose of the project is to use the acquired knowledge to further increase the cytotoxity of hepatic NK cells and to eradicate hepatic metastasis of colon carcinoma . In a parallel project we will study pit cells, Kupffer cells and CC531s cells during their cytotoxic interaction in situ by confocal laser scanning microscopy.
Effective start/end date1/01/9731/12/03


  • Cell Biology
  • Hepatology
  • Oncology

Flemish discipline codes in use since 2023

  • Basic sciences


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