The role of the circadian machinery in tumour immunity and premetastatic niche formation

Project Details

Description

Majority of breast tumours are non-hereditary, driven by environmental factors that may include circadian disruption.
The circadian clock is a critical machinery of living organisms to adapt their physiology and behaviour to day-night cycles.
This mechanism has been found to regulate several cancer hallmarks including immune responses.
Recently, I showed that chronic circadian rhythm disruption (CRD) enhances metastasis and alters the tumour immune
microenvironment. Yet, the role of circadian mechanisms in these processes are poorly understood.
Therefore, this project aims to unravel the role of circadian disruption in tumor immunity.
We will investigate in vivo syngeneic murine tumour models to decipher the role of circadian clock in inflammation,
TAM polarization and early metastatic spread.
The results will provide novel insight into the role of circadian clock in anti-tumour immunity and tumour immune evasion.
AcronymFWOTM1042
StatusActive
Effective start/end date1/11/2131/10/24

Keywords

  • Macrophages/tumour-associated macrophages
  • circadian rhythm
  • pre-metastatic niche

Flemish discipline codes in use since 2023

  • Inflammation
  • Cancer biology
  • Cancer therapy
  • Immunology not elsewhere classified

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