Therapeutic hypothermia to improve neurological outcome in ischemic stroke.

  • Michotte, Yvette (Administrative Promotor)
  • Sarre, Sophie, (Co-Promotor)
  • Zgavc, Tine, (Collaborator)
  • Idrissi, Said (Co-Promotor)
  • De Raedt, Sylvie (Collaborator)

Project Details


Our project consists of two parts: a clinical and an experimental part.

In the clinical part, we want to perform a randomized, prospective, controlled, safety and feasibility trial comparing two treatments: "Standard 'best medical therapy'" vs. "Standard 'best medical therapy' plus induced minimal hypothermia (IMH) in patients presenting with an AIS within 8 hours after onset of symptoms. Minimal hypothermia (35°C) will be induced for 72 hours in patients randomized to the hypothermia-arm. Mepederine and buspirone will be, if needed, associated to suppress shivering. Minimal hypothermia will be induced by using our helmet device and as soon as the target temperature (TT) is achieved, the endovascular cooling device will be used to maintain the TT.

In the experimental part, in support of the clinical study, we aim to further investigate the neuroprotective effects of hypothermia in the endothelin-1 (Et-1) rat model focusing on the important parameters necessary for a better transfer to the clinical situation. Using the same protocol as in our previous studies, we will determine the degree of apoptosis, inflammation and glycemia 24hrs, 72hrs and 1 week after the insult. At each time point, we will also determine the neurological outcome of the rats using the 'neurological deficit score' and the 'sensory neglect' method. Then we will investigate the effect of hypothermia on these parameters. We will compare hypothermia duration of 20 minutes with that of 3 hours. There will be a constant reciprocal feedback of fundamental research data to the clinicians so that changes in protocol are possible (both fundamental and clinical).

Our project intends to reveal not only the feasibility and the safety of IMH in the treatment of patients presenting with an AIS. We aim also to improve the neurological and functional outcome in those patients.

After concluding our project, we plan to establish a protocol for a larger randomized controlled multicentric prospective trial to reveal to which extent induced hypothermia (IH) improves neurological and functional outcome after moderate and severe AIS.


Effective start/end date1/09/0731/08/10


  • stroke
  • hypothermia
  • pharmacology

Flemish discipline codes

  • Basic sciences