Unraveling the pathways of permeability Barrier homeostasis: the cross-talk between corneum stress events and signalling transduction within the viable epidermis.

Project Details


"La raison d'être" of the epidermis, as beautifully portrayed by Kathy Madison in the journal of Investigative Dermatology (J Invest Dermatol. 2003 Aug; 121 (2):231-41), describes the primary function of the skin: The terminal differentiation of an initially multipotent stem cell produces a protective, semi-permeable stratum corneum (SC) that permits terrestrial life. The permeability barrier function of the SC is provided by lipid bilayers lamellae surrounding anucleated apoptic corneocytes. This structure has been described by Peter Elias as the "Bricks and mortar" model where the bricks are the corneocytes and the mortar refers to the adjoining lipids. In the current project we hypothesize that Protease activated receptor 2(PAR2)-caveolae coupling regulates permeability barrier homeostasis by sensing acute perturbations inthe SC? Signaling transduction events within the viable underlying epidermis occuring through PAR2 activation and caveolae mobilization may lead to: 1) the lipid rafts/caveola arrangments with the consequent control of lamellar bodies secretion and 2) the apoptic formation of corneocytes by the activation of executor and/or differentiation-related caspases. To understand the mechanisms that drive barrier formation, we adress is this project the signaling eventsoccuring under both physiologic and pathologic conditions that are responsible for lamellar bodies secretion (LB) and corneocyte formation.
Effective start/end date1/01/0731/12/07


  • medicine

Flemish discipline codes

  • Basic sciences