Unraveling the pathways of permeability Barrier homeostasis: the cross-talk between corneum stress events and signalling transduction within the viable epidermis.

Project Details


"La raison d'être" of the epidermis, as beautifully portrayed by Kathy Madison in the journal of Investigative Dermatology (J Invest Dermatol. 2003 Aug; 121 (2):231-41), describes the primary function of the skin: The terminal differentiation of an initially multipotent stem cell produces a protective, semi-permeable stratum corneum (SC) that permits terrestrial life. The permeability barrier function of the SC is provided by lipid bilayers lamellae surrounding anucleated apoptic corneocytes.
Effective start/end date1/01/0731/12/10

Flemish discipline codes

  • Basic sciences


  • medicine