Research output per year
Research output per year
Search results
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2024
Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies
Galicia, C., Guaitoli, G., Fislage, M., Gloeckner, C. J. & Versées, W., 26 Apr 2024, In: eLife. 13, p. 1-23 23 p., RP94503.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)12 Downloads (Pure) -
2023
Nanobodies as versatile tools to unravel the mechanism and modulate the activity of key proteins in Parkinson’s disease
Galicia Diaz Santana, C., Dal Maso, T., Martin, E. & Versées, W., 2023.Research output: Unpublished contribution to conference › Poster
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2022
Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2
Singh, R. K., Soliman, A., Guaitoli, G., Störmer, E., von Zweydorf, F., Dal Maso, T., Oun, A., Van Rillaer, L., Schmidt, S. H., Chatterjee, D., David, J. A., Pardon, E., Schwartz, T. U., Knapp, S., Kennedy, E. J., Steyaert, J., Herberg, F. W., Kortholt, A., Gloeckner, C. J. & Versées, W., 1 Mar 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 9, p. 1-12 12 p., e2112712119.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)164 Downloads (Pure) -
2021
Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides
Helton, L. G., von Zweydorf, F., Kentros, M., Manschwetus, J. T., Hall, S., Gilsbach, B., Ho, F. Y., Athanasopoulos, P. S., Singh, R. K., LeClair, T. J., Versées, W., Raimondi, F., Herberg, F. W., Gloeckner, C. J., Rideout, H., Kortholt, A. & Kennedy, E. J., 19 Nov 2021, In: ACS Chemical Biology. 16, 11, p. 2326-2338 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)118 Downloads (Pure) -
Leucine-rich repeat kinase 2 allosteric modulators
Versées, W., Singh, R. K., Kortholt, A. & Gloeckner, C. J., 2021, Patent No. WO2021170540Research output: Patent
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Nanobodies to allosterically modulate the GTPase activity of a LRRK2 homolog.
Galicia Diaz Santana, C., Leemans, M., Deyaert, E., Singh, R. K. & Versées, W., 21 May 2021.Research output: Unpublished contribution to conference › Poster
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2020
Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies
Leemans, M., Galicia, C., Deyaert, E., Daems, E., Krause, L., Paesmans, J., Pardon, E., Steyaert, J., Kortholt, A., Sobott, F., Klostermeier, D. & Versees, W., 17 Apr 2020, In: Biochemical Journal. 477, 7, p. 1203-1218 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)78 Downloads (Pure) -
2019
Roco Proteins: GTPases with a Baroque Structure and Mechanism
Wauters, L., Versées, W. & Kortholt, A., 3 Jan 2019, In: International Journal of Molecular Sciences. 20, 1, 21 p., 147.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)60 Downloads (Pure) -
Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum Roco protein
Deyaert, E., Leemans, M., Singh, R. K., Gallardo, R., Steyaert, J., Kortholt, A., Lauer, J. & Versées, W., 15 Jan 2019, In: Biochemical Journal. 476, 1, p. 51-66 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)471 Downloads (Pure)