64-Slice CT angiography of the abdominal aorta and abdominal arteries: comparison of the diagnostic efficacy of iobitridol 350 mgI/ml versus iomeprol 400 mgI/ml in a prospective, randomised, double-blind multi-centre trial.

C. Loewe, C.r. Becker, R. Berletti, C.a. Cametti, J. Caudron, W. Coudyzer, Johan De Mey, M. Favat, J.-F. Heautot, S Heye, M. Hittinger, A. Larralde, J.-P. Lestrat, R. Marangoni, K Nieboer, P. Reimer, M. Schwarz, M. Schernthaner, J. Lammer

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Abstract

PURPOSE: The purpose of this study was to assess the influence of iodine
concentration on diagnostic efficacy in multi-detector-row computed tomography
(MDCT) angiography of the abdominal aorta and abdominal arteries.
METHODS: IRB approval and informed consent were obtained. In this double-blind
trial, patients were randomised to undergo MDCT angiography of the abdominal
arteries during administration of iobitridol (350 mgI/ml) or iomeprol (400
mgI/ml). Each centre applied its own technique for delivery of contrast medium,
regardless of iodine concentration. Diagnostic efficacy, image quality,
visualisation of the arterial wall and arterial enhancement were evaluated. A
total of 153 patients received iobitridol and 154 received iomeprol.
RESULTS: The ability to reach a diagnosis was "satisfactory" to "totally
satisfactory" in 152 (99.3%) and 153 (99.4%) patients respectively. Image quality
was rated as being "good" to "excellent" in 94.7 and 94.8% segments respectively.
Similar results were observed for image quality of arterial walls (84.3 vs.
83.2%). The mean relative changes in arterial enhancement between baseline and
arterial phase images showed no statistically significant differences.
CONCLUSION: This study demonstrated the non-inferiority of the 350 versus 400
mgI/ml iodine concentration, in terms of diagnostic efficacy, in abdominal MDCT
angiography. It also confirmed the high robustness and reliability of this
technique across multi-national practices.
Original languageEnglish
Pages (from-to)572-583
Number of pages12
JournalEur Radiol
Volume20
Publication statusPublished - 2010

Keywords

  • 64-slice CT
  • abdominal aorta

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