64-Slice CT angiography of the abdominal aorta and abdominal arteries: comparison
of the diagnostic efficacy of iobitridol 350 mgI/ml versus iomeprol 400 mgI/ml in
a prospective, randomised, double-blind multi-centre trial.

C. Loewe; C.r. Becker; R. Berletti; C.a. Cametti; J. Caudron; W. Coudyzer; Johan De Mey; M. Favat; J.-F. Heautot; S Heye; M. Hittinger; A. Larralde; J.-P. Lestrat; R. Marangoni; K Nieboer; P. Reimer; M. Schwarz; M. Schernthaner; J. Lammer

64-Slice CT angiography of the abdominal aorta and abdominal arteries: comparison of the diagnostic efficacy of iobitridol 350 mgI/ml versus iomeprol 400 mgI/ml in a prospective, randomised, double-blind multi-centre trial.

C. Loewe, C.r. Becker, R. Berletti, C.a. Cametti, J. Caudron, W. Coudyzer, Johan De Mey, M. Favat, J.-F. Heautot, S Heye, M. Hittinger, A. Larralde, J.-P. Lestrat, R. Marangoni, K Nieboer, P. Reimer, M. Schwarz, M. Schernthaner, J. Lammer

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

PURPOSE: The purpose of this study was to assess the influence of iodine
concentration on diagnostic efficacy in multi-detector-row computed tomography
(MDCT) angiography of the abdominal aorta and abdominal arteries.
METHODS: IRB approval and informed consent were obtained. In this double-blind
trial, patients were randomised to undergo MDCT angiography of the abdominal
arteries during administration of iobitridol (350 mgI/ml) or iomeprol (400
mgI/ml). Each centre applied its own technique for delivery of contrast medium,
regardless of iodine concentration. Diagnostic efficacy, image quality,
visualisation of the arterial wall and arterial enhancement were evaluated. A
total of 153 patients received iobitridol and 154 received iomeprol.
RESULTS: The ability to reach a diagnosis was "satisfactory" to "totally
satisfactory" in 152 (99.3%) and 153 (99.4%) patients respectively. Image quality
was rated as being "good" to "excellent" in 94.7 and 94.8% segments respectively.
Similar results were observed for image quality of arterial walls (84.3 vs.
83.2%). The mean relative changes in arterial enhancement between baseline and
arterial phase images showed no statistically significant differences.
CONCLUSION: This study demonstrated the non-inferiority of the 350 versus 400
mgI/ml iodine concentration, in terms of diagnostic efficacy, in abdominal MDCT
angiography. It also confirmed the high robustness and reliability of this
technique across multi-national practices.

Original language	English
Pages (from-to)	572-583
Number of pages	12
Journal	Eur Radiol
Volume	20
Publication status	Published - 2010

Keywords

64-slice CT
abdominal aorta

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Loewe, C., Becker, C. R., Berletti, R., Cametti, C. A., Caudron, J., Coudyzer, W., De Mey, J., Favat, M., Heautot, J-F., Heye, S., Hittinger, M., Larralde, A., Lestrat, J-P., Marangoni, R., Nieboer, K., Reimer, P., Schwarz, M., Schernthaner, M., & Lammer, J. (2010). 64-Slice CT angiography of the abdominal aorta and abdominal arteries: comparison of the diagnostic efficacy of iobitridol 350 mgI/ml versus iomeprol 400 mgI/ml in a prospective, randomised, double-blind multi-centre trial. Eur Radiol, 20, 572-583.

Loewe, C. ; Becker, C.r. ; Berletti, R. ; Cametti, C.a. ; Caudron, J. ; Coudyzer, W. ; De Mey, Johan ; Favat, M. ; Heautot, J.-F. ; Heye, S ; Hittinger, M. ; Larralde, A. ; Lestrat, J.-P. ; Marangoni, R. ; Nieboer, K ; Reimer, P. ; Schwarz, M. ; Schernthaner, M. ; Lammer, J. / 64-Slice CT angiography of the abdominal aorta and abdominal arteries: comparison of the diagnostic efficacy of iobitridol 350 mgI/ml versus iomeprol 400 mgI/ml in a prospective, randomised, double-blind multi-centre trial. In: Eur Radiol. 2010 ; Vol. 20. pp. 572-583.

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title = "64-Slice CT angiography of the abdominal aorta and abdominal arteries: comparison of the diagnostic efficacy of iobitridol 350 mgI/ml versus iomeprol 400 mgI/ml in a prospective, randomised, double-blind multi-centre trial.",

abstract = "PURPOSE: The purpose of this study was to assess the influence of iodine concentration on diagnostic efficacy in multi-detector-row computed tomography (MDCT) angiography of the abdominal aorta and abdominal arteries. METHODS: IRB approval and informed consent were obtained. In this double-blind trial, patients were randomised to undergo MDCT angiography of the abdominal arteries during administration of iobitridol (350 mgI/ml) or iomeprol (400 mgI/ml). Each centre applied its own technique for delivery of contrast medium, regardless of iodine concentration. Diagnostic efficacy, image quality, visualisation of the arterial wall and arterial enhancement were evaluated. A total of 153 patients received iobitridol and 154 received iomeprol. RESULTS: The ability to reach a diagnosis was {"}satisfactory{"} to {"}totally satisfactory{"} in 152 (99.3%) and 153 (99.4%) patients respectively. Image quality was rated as being {"}good{"} to {"}excellent{"} in 94.7 and 94.8% segments respectively. Similar results were observed for image quality of arterial walls (84.3 vs. 83.2%). The mean relative changes in arterial enhancement between baseline and arterial phase images showed no statistically significant differences. CONCLUSION: This study demonstrated the non-inferiority of the 350 versus 400 mgI/ml iodine concentration, in terms of diagnostic efficacy, in abdominal MDCT angiography. It also confirmed the high robustness and reliability of this technique across multi-national practices.",

keywords = "64-slice CT, abdominal aorta",

author = "C. Loewe and C.r. Becker and R. Berletti and C.a. Cametti and J. Caudron and W. Coudyzer and {De Mey}, Johan and M. Favat and J.-F. Heautot and S Heye and M. Hittinger and A. Larralde and J.-P. Lestrat and R. Marangoni and K Nieboer and P. Reimer and M. Schwarz and M. Schernthaner and J. Lammer",

year = "2010",

language = "English",

volume = "20",

pages = "572--583",

journal = "European Radiology",

issn = "0938-7994",

publisher = "Springer Verlag",

}

Loewe, C, Becker, CR, Berletti, R, Cametti, CA, Caudron, J, Coudyzer, W, De Mey, J, Favat, M, Heautot, J-F, Heye, S, Hittinger, M, Larralde, A, Lestrat, J-P, Marangoni, R, Nieboer, K, Reimer, P, Schwarz, M, Schernthaner, M & Lammer, J 2010, '64-Slice CT angiography of the abdominal aorta and abdominal arteries: comparison of the diagnostic efficacy of iobitridol 350 mgI/ml versus iomeprol 400 mgI/ml in a prospective, randomised, double-blind multi-centre trial.', Eur Radiol, vol. 20, pp. 572-583.

64-Slice CT angiography of the abdominal aorta and abdominal arteries: comparison of the diagnostic efficacy of iobitridol 350 mgI/ml versus iomeprol 400 mgI/ml in a prospective, randomised, double-blind multi-centre trial. / Loewe, C.; Becker, C.r.; Berletti, R.; Cametti, C.a.; Caudron, J.; Coudyzer, W.; De Mey, Johan; Favat, M.; Heautot, J.-F.; Heye, S; Hittinger, M.; Larralde, A.; Lestrat, J.-P.; Marangoni, R.; Nieboer, K; Reimer, P.; Schwarz, M.; Schernthaner, M.; Lammer, J.

In: Eur Radiol, Vol. 20, 2010, p. 572-583.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - 64-Slice CT angiography of the abdominal aorta and abdominal arteries: comparison of the diagnostic efficacy of iobitridol 350 mgI/ml versus iomeprol 400 mgI/ml in a prospective, randomised, double-blind multi-centre trial.

AU - Loewe, C.

AU - Becker, C.r.

AU - Berletti, R.

AU - Cametti, C.a.

AU - Caudron, J.

AU - Coudyzer, W.

AU - De Mey, Johan

AU - Favat, M.

AU - Heautot, J.-F.

AU - Heye, S

AU - Hittinger, M.

AU - Larralde, A.

AU - Lestrat, J.-P.

AU - Marangoni, R.

AU - Nieboer, K

AU - Reimer, P.

AU - Schwarz, M.

AU - Schernthaner, M.

AU - Lammer, J.

PY - 2010

Y1 - 2010

N2 - PURPOSE: The purpose of this study was to assess the influence of iodine concentration on diagnostic efficacy in multi-detector-row computed tomography (MDCT) angiography of the abdominal aorta and abdominal arteries. METHODS: IRB approval and informed consent were obtained. In this double-blind trial, patients were randomised to undergo MDCT angiography of the abdominal arteries during administration of iobitridol (350 mgI/ml) or iomeprol (400 mgI/ml). Each centre applied its own technique for delivery of contrast medium, regardless of iodine concentration. Diagnostic efficacy, image quality, visualisation of the arterial wall and arterial enhancement were evaluated. A total of 153 patients received iobitridol and 154 received iomeprol. RESULTS: The ability to reach a diagnosis was "satisfactory" to "totally satisfactory" in 152 (99.3%) and 153 (99.4%) patients respectively. Image quality was rated as being "good" to "excellent" in 94.7 and 94.8% segments respectively. Similar results were observed for image quality of arterial walls (84.3 vs. 83.2%). The mean relative changes in arterial enhancement between baseline and arterial phase images showed no statistically significant differences. CONCLUSION: This study demonstrated the non-inferiority of the 350 versus 400 mgI/ml iodine concentration, in terms of diagnostic efficacy, in abdominal MDCT angiography. It also confirmed the high robustness and reliability of this technique across multi-national practices.

AB - PURPOSE: The purpose of this study was to assess the influence of iodine concentration on diagnostic efficacy in multi-detector-row computed tomography (MDCT) angiography of the abdominal aorta and abdominal arteries. METHODS: IRB approval and informed consent were obtained. In this double-blind trial, patients were randomised to undergo MDCT angiography of the abdominal arteries during administration of iobitridol (350 mgI/ml) or iomeprol (400 mgI/ml). Each centre applied its own technique for delivery of contrast medium, regardless of iodine concentration. Diagnostic efficacy, image quality, visualisation of the arterial wall and arterial enhancement were evaluated. A total of 153 patients received iobitridol and 154 received iomeprol. RESULTS: The ability to reach a diagnosis was "satisfactory" to "totally satisfactory" in 152 (99.3%) and 153 (99.4%) patients respectively. Image quality was rated as being "good" to "excellent" in 94.7 and 94.8% segments respectively. Similar results were observed for image quality of arterial walls (84.3 vs. 83.2%). The mean relative changes in arterial enhancement between baseline and arterial phase images showed no statistically significant differences. CONCLUSION: This study demonstrated the non-inferiority of the 350 versus 400 mgI/ml iodine concentration, in terms of diagnostic efficacy, in abdominal MDCT angiography. It also confirmed the high robustness and reliability of this technique across multi-national practices.

KW - 64-slice CT

KW - abdominal aorta

M3 - Article

VL - 20

SP - 572

EP - 583

JO - European Radiology

JF - European Radiology

SN - 0938-7994

ER -