We have described the convergent features of single-chain antibodies that permitted their emergence and reemergence and the constraints that may have precluded their existence in all vertebrates. On the basis of recent discoveries, it is possible that they will be found in other species as well, either as an Ig or a TCR. Single-domain Vs have a growing repertoire of uses in both clinical and basic research, a testament to their complement of the conventional VH/VL antibodies; basic research on the animals that have naturally evolved such antibodies will provide refined theories of their dedicated functions, and give greater insight to their emergence several times in vertebrate history.
|Number of pages||1|
|Publication status||Published - 1 Aug 2011|
- Single-chain antibodies
- heavy-chain antibody
- T-cell receptors