A case of convergence : why did a simple alternative to canonical antibodies arise in sharks and camels?

Martin F. Flajnik, Nick Deschacht, Serge Muyldermans

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

We have described the convergent features of single-chain antibodies that permitted their emergence and reemergence and the constraints that may have precluded their existence in all vertebrates. On the basis of recent discoveries, it is possible that they will be found in other species as well, either as an Ig or a TCR. Single-domain Vs have a growing repertoire of uses in both clinical and basic research, a testament to their complement of the conventional VH/VL antibodies; basic research on the animals that have naturally evolved such antibodies will provide refined theories of their dedicated functions, and give greater insight to their emergence several times in vertebrate history.
Original languageEnglish
Pages (from-to)1001120
Number of pages1
JournalPLoS Biology
Volume9
Issue number8
Publication statusPublished - 1 Aug 2011

Keywords

  • Single-chain antibodies
  • heavy-chain antibody
  • Immunoglobulin
  • T-cell receptors

Fingerprint Dive into the research topics of 'A case of convergence : why did a simple alternative to canonical antibodies arise in sharks and camels?'. Together they form a unique fingerprint.

Cite this