A role for leptin in the systemic inflammatory response syndrome (SIRS) and in immune response, an update.

W Waelput, P Brouckaert, D Broekaert, J Tavernier

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Leptin was originally identified as an adipocyte-derived cytokine with a key role in the regulation of the energy balance. Subsequent research revealed that leptin's biological action is not restricted to its effects on appetite and food intake, but instead has a much more pleiotropic character. There is now ample evidence that leptin has important functions in reproduction, hematopoiesis, HPA-axis endocrinology and angiogenesis. In this review we have focused on the effects of leptin in the antigen-specific immunity and in the inflammatory effector system.
Original languageEnglish
Pages (from-to)465-475
Number of pages11
JournalCurrent Medicinal Chemistry
Issue number4
Publication statusPublished - Jan 2006


  • Adaptation, Physiological
  • Animals
  • Anorexia
  • Anorexia: physiopathology
  • Humans
  • Immunity
  • Immunity: physiology
  • Inflammation
  • Inflammation: physiopathology
  • Leptin
  • Leptin: physiology
  • Macrophages
  • Macrophages: drug effects
  • Macrophages: physiology
  • Metallothionein
  • Metallothionein: biosynthesis
  • Monocytes
  • Monocytes: drug effects
  • Monocytes: physiology
  • Receptors, Cell Surface
  • Receptors, Cell Surface: physiology
  • Receptors, Leptin
  • Starvation
  • Starvation: physiopathology
  • Systemic Inflammatory Response Syndrome
  • Systemic Inflammatory Response Syndrome: physiopat
  • T-Lymphocytes
  • T-Lymphocytes: physiology
  • alpha-MSH
  • alpha-MSH: physiology


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