Abstract
Leptin was originally identified as an adipocyte-derived cytokine with a key role in the regulation of the energy balance. Subsequent research revealed that leptin's biological action is not restricted to its effects on appetite and food intake, but instead has a much more pleiotropic character. There is now ample evidence that leptin has important functions in reproduction, hematopoiesis, HPA-axis endocrinology and angiogenesis. In this review we have focused on the effects of leptin in the antigen-specific immunity and in the inflammatory effector system.
| Original language | English |
|---|---|
| Pages (from-to) | 465-475 |
| Number of pages | 11 |
| Journal | Current Medicinal Chemistry |
| Volume | 13 |
| Issue number | 4 |
| Publication status | Published - Jan 2006 |
Keywords
- Adaptation, Physiological
- Animals
- Anorexia
- Anorexia: physiopathology
- Humans
- Immunity
- Immunity: physiology
- Inflammation
- Inflammation: physiopathology
- Leptin
- Leptin: physiology
- Macrophages
- Macrophages: drug effects
- Macrophages: physiology
- Metallothionein
- Metallothionein: biosynthesis
- Monocytes
- Monocytes: drug effects
- Monocytes: physiology
- Receptors, Cell Surface
- Receptors, Cell Surface: physiology
- Receptors, Leptin
- Starvation
- Starvation: physiopathology
- Systemic Inflammatory Response Syndrome
- Systemic Inflammatory Response Syndrome: physiopat
- T-Lymphocytes
- T-Lymphocytes: physiology
- alpha-MSH
- alpha-MSH: physiology