Ablation for the treatment of Brugada syndrome: current status and future prospects

Research output: Contribution to journalScientific review

2 Citations (Scopus)

Abstract

Introduction: Brugada syndrome (BrS) is an inherited disease characterized by an increased risk of sudden cardiac death (SCD). Therapeutic options in symptomatic patients are limited to implantable cardioverter defibrillator (ICD) and quinidine, but catheter ablation of the right ventricular outflow tract (RVOT) offers a potential cure. Different ablation strategies have been used to treat patients with symptomatic Brugada syndrome. Epicardial radiofrequency substrate ablation of the RVOT/right ventricle (RV) has emerged as a promising tool for the management of the disease.Areas covered: The historical management of BrS, endocardial and epicardial ablation techniques, the use of sodium channel blockers (SCB) and complications are summarized here.Expert opinion: Ventricular fibrillation (VF)-triggering premature ventricular contractions (PVCs) in patients with BrS are unpredictable, spontaneous ones are rarely present to be mapped, making this approach impractical. Furthermore, endocardial mapping for BrS substrates does not seem effective due to the epicardial pathological substrate localization. The size variation of the BrS substrate areas during SCB infusion suggests a dynamic process as arrhythmogenic basis and SCB infusion should guide BrS epicardial ablation of all abnormal potentials areas. If BrS epicardial ablation can truly provide long-term prevention of ventricular arrhythmias it may potentially become an alternative to ICD therapy.

Original languageEnglish
Pages (from-to)123-130
Number of pages8
JournalExpert Review of Medical Devices
Volume17
Issue number2
Early online date27 Jan 2020
DOIs
Publication statusPublished - 1 Feb 2020

Keywords

  • Brugada syndrome
  • ICD
  • catheter radiofrequency ablation
  • epicardial substrate ablation
  • hybrid thoracoscopic ablation
  • right ventricle outflow tract conduction delay;
  • sodium channel blockers
  • sudden cardiac death
  • ventricular fibrillation triggers

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