Accessory cells for beta cell transplantation

Willem Staels, Sofie De Groef, Yves Heremans, Violette Coppens, Naomi Van Gassen, Gunter Leuckx, Mark Van de Casteele, Ivan Van Riet, Aernout Luttun, Henry Heimberg, Nico De Leu

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Despite recent advances, insulin therapy remains a treatment, not a cure, for diabetes mellitus with persistent risk of glycemic alterations and life-threatening complications. Restoration of the endogenous beta cell mass through regeneration or transplantation offers an attractive alternative. Unfortunately, signals that drive beta cell regeneration remain enigmatic and beta cell replacement therapy still faces major hurdles that prevent its widespread application. Co-transplantation of accessory non-islet cells with islet cells has been shown to improve the outcome of experimental islet transplantation. This review will highlight current travails in beta cell therapy and focuses on the potential benefits of accessory cells for islet transplantation in diabetes.

Original languageEnglish
Pages (from-to)115-124
Number of pages9
JournalDiabetes, Obesity and Metabolism
Volume18
Issue number2
Early online date20 Aug 2015
DOIs
Publication statusPublished - Feb 2016

Keywords

  • beta cells
  • diabetes
  • transplantation
  • accessory cells
  • Review

Fingerprint

Dive into the research topics of 'Accessory cells for beta cell transplantation'. Together they form a unique fingerprint.

Cite this