Accessory cells for beta cell transplantation

Willem Staels; Sofie De Groef; Yves Heremans; Violette Coppens; Naomi Van Gassen; Gunter Leuckx; Mark Van de Casteele; Ivan Van Riet; Aernout Luttun; Henry Heimberg; Nico De Leu

doi:10.1111/dom.12556

Accessory cells for beta cell transplantation

Willem Staels, Sofie De Groef, Yves Heremans, Violette Coppens, Naomi Van Gassen, Gunter Leuckx, Mark Van de Casteele, Ivan Van Riet, Aernout Luttun, Henry Heimberg, Nico De Leu

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Despite recent advances, insulin therapy remains a treatment, not a cure, for diabetes mellitus with persistent risk of glycemic alterations and life-threatening complications. Restoration of the endogenous beta cell mass through regeneration or transplantation offers an attractive alternative. Unfortunately, signals that drive beta cell regeneration remain enigmatic and beta cell replacement therapy still faces major hurdles that prevent its widespread application. Co-transplantation of accessory non-islet cells with islet cells has been shown to improve the outcome of experimental islet transplantation. This review will highlight current travails in beta cell therapy and focuses on the potential benefits of accessory cells for islet transplantation in diabetes.

Original language	English
Pages (from-to)	115-124
Number of pages	9
Journal	Diabetes, Obesity and Metabolism
Volume	18
Issue number	2
Early online date	20 Aug 2015
DOIs	https://doi.org/10.1111/dom.12556
Publication status	Published - Feb 2016

Keywords

beta cells
diabetes
transplantation
accessory cells
Review

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10.1111/dom.12556

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title = "Accessory cells for beta cell transplantation",

abstract = "Despite recent advances, insulin therapy remains a treatment, not a cure, for diabetes mellitus with persistent risk of glycemic alterations and life-threatening complications. Restoration of the endogenous beta cell mass through regeneration or transplantation offers an attractive alternative. Unfortunately, signals that drive beta cell regeneration remain enigmatic and beta cell replacement therapy still faces major hurdles that prevent its widespread application. Co-transplantation of accessory non-islet cells with islet cells has been shown to improve the outcome of experimental islet transplantation. This review will highlight current travails in beta cell therapy and focuses on the potential benefits of accessory cells for islet transplantation in diabetes.",

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AU - Staels, Willem

AU - De Groef, Sofie

AU - Heremans, Yves

AU - Coppens, Violette

AU - Van Gassen, Naomi

AU - Leuckx, Gunter

AU - Van de Casteele, Mark

AU - Van Riet, Ivan

AU - Luttun, Aernout

AU - Heimberg, Henry

AU - De Leu, Nico

PY - 2016/2

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AB - Despite recent advances, insulin therapy remains a treatment, not a cure, for diabetes mellitus with persistent risk of glycemic alterations and life-threatening complications. Restoration of the endogenous beta cell mass through regeneration or transplantation offers an attractive alternative. Unfortunately, signals that drive beta cell regeneration remain enigmatic and beta cell replacement therapy still faces major hurdles that prevent its widespread application. Co-transplantation of accessory non-islet cells with islet cells has been shown to improve the outcome of experimental islet transplantation. This review will highlight current travails in beta cell therapy and focuses on the potential benefits of accessory cells for islet transplantation in diabetes.

KW - beta cells

KW - diabetes

KW - transplantation

KW - accessory cells

KW - Review

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DO - 10.1111/dom.12556

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JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

IS - 2

ER -

Accessory cells for beta cell transplantation

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Keywords

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