Activation-induced surface proteins in the identification of antigen-responsive CD4 T cells

George Elias, Benson Ogunjimi, Viggo Van Tendeloo

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Identification of antigen specificity of CD4 T cells is instrumental in understanding adaptive immune responses in health and disease. The high diversity of CD4 T cell repertoire combined with the functional heterogeneity of the compartment poses a challenge to the assessment of CD4 T cell responses. In spite of that, multiple technologies allow direct or indirect interrogation of antigen specificity of CD4 T cells. In the last decade, multiple surface proteins have been established as cytokine-independent surrogates of in vitro CD4 T cell activation, and have found applications in the live identification and isolation of antigen-responsive CD4 T cells. Here we review the current knowledge of the surface proteins that permit identification of viable antigen-responsive CD4 T cells with high specificity, including those capable of identifying specialized CD4 T subsets such as germinal center follicular helper T cells and CD4 regulatory T cells.

Original languageEnglish
Article number31881234
Pages (from-to)1-7
Number of pages7
JournalImmunology Letters
Publication statusPublished - Mar 2020

Bibliographical note

Copyright © 2019 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.


  • Animals
  • Antigens/immunology
  • Biomarkers
  • CD4-Positive T-Lymphocytes/immunology
  • Cell Communication
  • Gene Expression
  • Homeostasis
  • Humans
  • Immunomodulation
  • Immunophenotyping
  • Lymphocyte Activation/immunology
  • Membrane Proteins/genetics
  • Signal Transduction
  • T-Lymphocyte Subsets/immunology


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