Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives

Belgian Diabetes Registry

Research output: Contribution to journalArticlepeer-review

Abstract

AIMS/HYPOTHESIS: Insulin resistance has been proposed as a risk factor for type 1 diabetes. We investigated whether adiponectin, an insulin sensitiser, can serve as an additional predictive marker for type 1 diabetes in first-degree relatives of known patients.

METHODS: Adiponectin was followed in 211 persistently islet antibody-positive (Ab+) first-degree relatives of type 1 diabetic patients and in 211 age- and sex-matched persistently antibody-negative relatives, and correlated with antibody status, random proinsulin:C-peptide ratio and HLA-DQ genotype. During follow-up, 37 Ab+ relatives developed type 1 diabetes.

RESULTS: In the group of 422 relatives, baseline adiponectin correlated inversely with age and BMI and was lower in male than in female participants, especially after 15 years of age (p < 0.001). There was no correlation with antibody status or later development of diabetes. In 24 Ab+ relatives sampled fasted, adiponectin levels correlated significantly with homeostasis model assessment of insulin sensitivity (p = 0.006). In Ab+ relatives (n = 211), adiponectin levels could not predict type 1 diabetes nor complement risk assessment based on islet antibodies, HLA-DQ genotype and pancreatic hormones in Cox regression analysis.

CONCLUSIONS/INTERPRETATION: Adiponectin levels do not contribute to the prediction of type 1 diabetes in Ab+ relatives.

Original languageEnglish
Pages (from-to)2143-2146
Number of pages4
JournalDiabetologia
Volume50
Issue number10
DOIs
Publication statusPublished - 2007

Keywords

  • Adiponectin/blood
  • Autoantibodies/blood
  • Biomarkers/blood
  • Cohort Studies
  • Diabetes Mellitus, Type 1/epidemiology
  • Female
  • HLA-DQ Antigens/genetics
  • Humans
  • Insulin Resistance
  • Male
  • Nuclear Family
  • Polymorphism, Genetic
  • Predictive Value of Tests

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