Advances in ultra‐high‐pressure and multi‐dimensional liquid chromatography instrumentation and workflows

Jelle De Vos, Dwight Stoll, Stephan Buckenmaier, Sebastiaan Eeltink, James Grinias

Research output: Contribution to journalArticle

Abstract

The present contribution discusses recent advances in ultra‐high‐pressure liquid chromatography (UHPLC) and multi‐dimensional liquid chromatography (MDLC) technology. First, new developments in UHPLC column technology and system design are highlighted. The latter includes a description of a novel injector concept enabling method speed‐up, emerging detectors, and instrument diagnostics approaches. Next, online MDLC workflows are reviewed and advances in modulation technology are highlighted. Finally, key applications published in 2020 are reviewed.
Original languageEnglish
Pages (from-to)1-22
Number of pages22
JournalAnalytical Science Advances
Early online date16 Mar 2021
DOIs
Publication statusE-pub ahead of print - 16 Mar 2021

Keywords

  • UHPLC
  • Two-dimensional liquid chromatography
  • 2D-LC
  • spatial 3D LC

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