Age Dependence of T1 Perfusion MRI-Based Hemodynamic Parameters in Human Kidneys

Martine Dujardin, Robert Luypaert, S. Soubron, Dierik Verbeelen, Tadeusz Stadnik, Johan De Mey

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


To determine the association between renal cortical perfusion parameters from T1-DCE magnetic resonance imaging (MRI) and age in human kidney.
Materials and Methods:
Thirty-five patients (mean age: 53 years, SD 15 years) were imaged using inversion recovery (IR)-prepared FLASH (pulse repitition time [TR] 4.4 msec, echo time [TE] 2.2 msec, inversion time [TI] 180 msec, FA 50°, matrix 128 x 256, 0.3 sec/slice) during the injection of Gadolinium-DTPA. Tissue concentration-time courses were deconvolved. Renal blood flow (RBF), volume of distribution (RVD), and mean transit time (MTT) were derived from the resulting impulse response function.
Mean RBF, RVD, and MTT were 127 mL/min/100 mL (SD 81 mL/min/100 mL), 40 mL/100 mL (SD 23 mL/100 mL), and 22 sec (SD 9 sec). A significant moderately negative correlation was found between RBF and age (R2=0.447, P = 0.007), RVD and age (R 2=0.420, P = 0.012). MTT and age did not show a significant correlation (R 2= 0.017, P = 0.924). Repeating this analysis for each gender revealed a moderate age dependence of RBF (R 2 = 0.600 with P = 0.009) and RVD (R 2 = 0.540 with P = 0.021) in the male group only.
T1-DCE quantitative perfusion MRI was sufficiently sensitive to demonstrate a significant negative correlation of RBF and RVD with patient age. This was due to a moderate age dependence of these quantities in males that seems to be absent in females.
Original languageEnglish
Pages (from-to)398-403
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Issue number2009
Publication statusPublished - 2009


  • kidney
  • perfusion
  • DCE


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