An integrative skeletal paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers

Stephanie Marciniak; Christina Bergey; Anna Maria  Silva; Agata Haluszko; Miroslaw Furmanek; Barbara Veselka; Petr Veleminsky; Giuseppe Vercellotti; Joachim Wahl; Gunita Zarina; Cristina Longhi; Jan Kolar; Rafael Garrido-Pena; Raul Flores-Fernandez; Anna M. Herrero-Corral; Angela Simalcsik; Werner Muller; Alison Sheridan; Zydrune Miliauskiene; Rimantas Jankauskas; Vyacheslav Moiseyev; Kitti Kohler; Agnes Kiraly; Beatriz Gamarra; Olivia Cheronet; Vajk Szeverenyi; Viktoria Kiss; Tamas Szeniczey; Krisztian Kiss; Zsuzsanna Zoffmann; Judit Koos; Magdolna Hellebrandt; Robert Maier; Laszlo Domboroczki; Cristian Virag; Mario Novak; David Reich; Tamas Hajdu; Noreen Von Cramon-Taubadel; Ron Pinhasi; George Perry

doi:10.1073/pnas.2106743119

An integrative skeletal paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers

Stephanie Marciniak, Christina Bergey, Anna Maria Silva, Agata Haluszko, Miroslaw Furmanek, Barbara Veselka, Petr Veleminsky, Giuseppe Vercellotti, Joachim Wahl, Gunita Zarina, Cristina Longhi, Jan Kolar, Rafael Garrido-Pena, Raul Flores-Fernandez, Anna M. Herrero-Corral, Angela Simalcsik, Werner Muller, Alison Sheridan, Zydrune Miliauskiene, Rimantas JankauskasVyacheslav Moiseyev, Kitti Kohler, Agnes Kiraly, Beatriz Gamarra, Olivia Cheronet, Vajk Szeverenyi, Viktoria Kiss, Tamas Szeniczey, Krisztian Kiss, Zsuzsanna Zoffmann, Judit Koos, Magdolna Hellebrandt, Robert Maier, Laszlo Domboroczki, Cristian Virag, Mario Novak, David Reich, Tamas Hajdu, Noreen Von Cramon-Taubadel, Ron Pinhasi, George Perry

History, Archeology, Arts, Philosophy and Ethics

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20 Citations (Scopus)

82 Downloads (Pure)

Abstract

SignificanceSubsistence shifts from hunting and gathering to agriculture over the last 12,000 y have impacted human culture, biology, and health. Although past human health cannot be assessed directly, adult stature variation and skeletal indicators of nonspecific stress can serve as proxies for health during growth and development. By integrating paleogenomic genotype and osteological stature data on a per-individual basis for 167 prehistoric Europeans, we observe relatively shorter than expected statures among early farmers after correcting for individual genetic contributions to stature. Poorer nutrition and/or increased disease burdens for early agriculturalists may partly underscore this result. Our integrated osteological-genetic model has exciting potential for studies of past human health and expansion into various other contexts.

Original language	English
Article number	e2106743119
Pages (from-to)	1-12
Number of pages	12
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	119
Issue number	15
DOIs	https://doi.org/10.1073/pnas.2106743119
Publication status	Published - 12 Apr 2022

Bibliographical note

Funding Information:
ACKNOWLEDGMENTS. We thank the many researchers and skeletal collections curators for their positive responses to us and their interest in this study, even when materials or data were unavailable for inclusion. Components of this work were supported by Wenner-Gren Foundation Grant 222377 (to S.M.), NIH Grant R01-GM115656 (to G.H.P.), and the Harry J. and Elissa M. Sichi Early Career Professorship in Anthropology (to G.H.P.). P.V. was supported by Ministry of Culture of the Czech Republic Grant DKRVO/2019-2023/7.I.d, National Museum, 00023272. J Kolá≤r was supported by Long-Term Development Project RV67985939 of the Institute of Botany of the Czech Academy of Sciences and Czech Science Foundation Grant 19-20970Y. B.G. was supported by Marie Skłodowska-Curie Grant H2020-MSCA-IF-2015 -703373. T.S., K.K., and T.H. were supported by a grant of Hungarian Research, Development and Innovation Office Projects FK128013 and K124326. M.N. was supported by Croatian Science Fund Grant HRZZ IP-2016-06-1450. G.H.P. thanks the DFG Center for Advanced Studies “Words, Bones, Genes, Tools” at the University of T€ubingen for support. Computations for this research were performed on the Pennsylvania State University’s Institute for Computational and Data Sciences’ supercomputing cluster. This content is solely the responsibility of the authors and does not necessarily represent the views of the Institute for Computational and Data Sciences.

Funding Information:
We thank the many researchers and skeletal collections curators for their positive responses to us and their interest in this study, even when materials or data were unavailable for inclusion. Components of this work were supported by Wenner-Gren Foundation Grant 222377 (to S.M.), NIH Grant R01-GM115656 (to G.H.P.), and the Harry J. and Elissa M. Sichi Early Career Professorship in Anthropology (to G.H.P.). P.V. was supported by Ministry of Culture of the Czech Republic Grant DKRVO/2019-2023/7.I.d, National Museum, 00023272. J Kolar was supported by Long-Term Development Project RV67985939 of the Institute of Botany of the Czech Academy of Sciences and Czech Science Foundation Grant 19-20970Y. B.G. was supported by Marie Skłodowska-Curie Grant H2020-MSCA-IF-2015 -703373. T.S., K.K., and T.H. were supported by a grant of Hungarian Research, Development and Innovation Office Projects FK128013 and K124326. M.N. was supported by Croatian Science Fund Grant HRZZ IP-2016-06-1450. G.H.P. thanks the DFG Center for Advanced Studies “Words, Bones, Genes, Tools” at the University of Tubingen for support. Computations for this research were performed on the Pennsylvania State University's Institute for Computational and Data Sciences' supercomputing cluster. This content is solely the responsibility of the authors and does not necessarily represent the views of the Institute for Computational and Data Sciences.

Publisher Copyright:
Copyright © 2022 the Author(s).

Copyright:
Copyright 2022 Elsevier B.V., All rights reserved.

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10.1073/pnas.2106743119Licence: CC BY-NC-ND

83435302Final published version, 1.84 MBLicence: CC BY-NC-ND

Cite this

Marciniak, S., Bergey, C., Silva, A. M., Haluszko, A., Furmanek, M., Veselka, B., Veleminsky, P., Vercellotti, G., Wahl, J., Zarina, G., Longhi, C., Kolar, J., Garrido-Pena, R., Flores-Fernandez, R., Herrero-Corral, A. M., Simalcsik, A., Muller, W., Sheridan, A., Miliauskiene, Z., ... Perry, G. (2022). An integrative skeletal paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers. Proceedings of the National Academy of Sciences of the United States of America, 119(15), 1-12. [e2106743119]. https://doi.org/10.1073/pnas.2106743119

Marciniak, Stephanie ; Bergey, Christina ; Silva, Anna Maria ; Haluszko, Agata ; Furmanek, Miroslaw ; Veselka, Barbara ; Veleminsky, Petr ; Vercellotti, Giuseppe ; Wahl, Joachim ; Zarina, Gunita ; Longhi, Cristina ; Kolar, Jan ; Garrido-Pena, Rafael ; Flores-Fernandez, Raul ; Herrero-Corral, Anna M. ; Simalcsik, Angela ; Muller, Werner ; Sheridan, Alison ; Miliauskiene, Zydrune ; Jankauskas, Rimantas ; Moiseyev, Vyacheslav ; Kohler, Kitti ; Kiraly, Agnes ; Gamarra, Beatriz ; Cheronet, Olivia ; Szeverenyi, Vajk ; Kiss, Viktoria ; Szeniczey, Tamas ; Kiss, Krisztian ; Zoffmann, Zsuzsanna ; Koos, Judit ; Hellebrandt, Magdolna ; Maier, Robert ; Domboroczki, Laszlo ; Virag, Cristian ; Novak, Mario ; Reich, David ; Hajdu, Tamas ; Von Cramon-Taubadel, Noreen ; Pinhasi, Ron ; Perry, George. / An integrative skeletal paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers. In: Proceedings of the National Academy of Sciences of the United States of America. 2022 ; Vol. 119, No. 15. pp. 1-12.

@article{8bbd871f6ebd476abd9921118a54ff53,

title = "An integrative skeletal paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers",

abstract = "SignificanceSubsistence shifts from hunting and gathering to agriculture over the last 12,000 y have impacted human culture, biology, and health. Although past human health cannot be assessed directly, adult stature variation and skeletal indicators of nonspecific stress can serve as proxies for health during growth and development. By integrating paleogenomic genotype and osteological stature data on a per-individual basis for 167 prehistoric Europeans, we observe relatively shorter than expected statures among early farmers after correcting for individual genetic contributions to stature. Poorer nutrition and/or increased disease burdens for early agriculturalists may partly underscore this result. Our integrated osteological-genetic model has exciting potential for studies of past human health and expansion into various other contexts.",

author = "Stephanie Marciniak and Christina Bergey and Silva, {Anna Maria} and Agata Haluszko and Miroslaw Furmanek and Barbara Veselka and Petr Veleminsky and Giuseppe Vercellotti and Joachim Wahl and Gunita Zarina and Cristina Longhi and Jan Kolar and Rafael Garrido-Pena and Raul Flores-Fernandez and Herrero-Corral, {Anna M.} and Angela Simalcsik and Werner Muller and Alison Sheridan and Zydrune Miliauskiene and Rimantas Jankauskas and Vyacheslav Moiseyev and Kitti Kohler and Agnes Kiraly and Beatriz Gamarra and Olivia Cheronet and Vajk Szeverenyi and Viktoria Kiss and Tamas Szeniczey and Krisztian Kiss and Zsuzsanna Zoffmann and Judit Koos and Magdolna Hellebrandt and Robert Maier and Laszlo Domboroczki and Cristian Virag and Mario Novak and David Reich and Tamas Hajdu and {Von Cramon-Taubadel}, Noreen and Ron Pinhasi and George Perry",

note = "Funding Information: ACKNOWLEDGMENTS. We thank the many researchers and skeletal collections curators for their positive responses to us and their interest in this study, even when materials or data were unavailable for inclusion. Components of this work were supported by Wenner-Gren Foundation Grant 222377 (to S.M.), NIH Grant R01-GM115656 (to G.H.P.), and the Harry J. and Elissa M. Sichi Early Career Professorship in Anthropology (to G.H.P.). P.V. was supported by Ministry of Culture of the Czech Republic Grant DKRVO/2019-2023/7.I.d, National Museum, 00023272. J Kol{\'a}≤r was supported by Long-Term Development Project RV67985939 of the Institute of Botany of the Czech Academy of Sciences and Czech Science Foundation Grant 19-20970Y. B.G. was supported by Marie Sk{\l}odowska-Curie Grant H2020-MSCA-IF-2015 -703373. T.S., K.K., and T.H. were supported by a grant of Hungarian Research, Development and Innovation Office Projects FK128013 and K124326. M.N. was supported by Croatian Science Fund Grant HRZZ IP-2016-06-1450. G.H.P. thanks the DFG Center for Advanced Studies “Words, Bones, Genes, Tools” at the University of T€ubingen for support. Computations for this research were performed on the Pennsylvania State University{\textquoteright}s Institute for Computational and Data Sciences{\textquoteright} supercomputing cluster. This content is solely the responsibility of the authors and does not necessarily represent the views of the Institute for Computational and Data Sciences. Funding Information: We thank the many researchers and skeletal collections curators for their positive responses to us and their interest in this study, even when materials or data were unavailable for inclusion. Components of this work were supported by Wenner-Gren Foundation Grant 222377 (to S.M.), NIH Grant R01-GM115656 (to G.H.P.), and the Harry J. and Elissa M. Sichi Early Career Professorship in Anthropology (to G.H.P.). P.V. was supported by Ministry of Culture of the Czech Republic Grant DKRVO/2019-2023/7.I.d, National Museum, 00023272. J Kolar was supported by Long-Term Development Project RV67985939 of the Institute of Botany of the Czech Academy of Sciences and Czech Science Foundation Grant 19-20970Y. B.G. was supported by Marie Sk{\l}odowska-Curie Grant H2020-MSCA-IF-2015 -703373. T.S., K.K., and T.H. were supported by a grant of Hungarian Research, Development and Innovation Office Projects FK128013 and K124326. M.N. was supported by Croatian Science Fund Grant HRZZ IP-2016-06-1450. G.H.P. thanks the DFG Center for Advanced Studies “Words, Bones, Genes, Tools” at the University of Tubingen for support. Computations for this research were performed on the Pennsylvania State University's Institute for Computational and Data Sciences' supercomputing cluster. This content is solely the responsibility of the authors and does not necessarily represent the views of the Institute for Computational and Data Sciences. Publisher Copyright: Copyright {\textcopyright} 2022 the Author(s). Copyright: Copyright 2022 Elsevier B.V., All rights reserved.",

year = "2022",

month = apr,

day = "12",

doi = "10.1073/pnas.2106743119",

language = "English",

volume = "119",

pages = "1--12",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

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Marciniak, S, Bergey, C, Silva, AM, Haluszko, A, Furmanek, M, Veselka, B, Veleminsky, P, Vercellotti, G, Wahl, J, Zarina, G, Longhi, C, Kolar, J, Garrido-Pena, R, Flores-Fernandez, R, Herrero-Corral, AM, Simalcsik, A, Muller, W, Sheridan, A, Miliauskiene, Z, Jankauskas, R, Moiseyev, V, Kohler, K, Kiraly, A, Gamarra, B, Cheronet, O, Szeverenyi, V, Kiss, V, Szeniczey, T, Kiss, K, Zoffmann, Z, Koos, J, Hellebrandt, M, Maier, R, Domboroczki, L, Virag, C, Novak, M, Reich, D, Hajdu, T, Von Cramon-Taubadel, N, Pinhasi, R & Perry, G 2022, 'An integrative skeletal paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 15, e2106743119, pp. 1-12. https://doi.org/10.1073/pnas.2106743119

An integrative skeletal paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers. / Marciniak, Stephanie; Bergey, Christina; Silva, Anna Maria ; Haluszko, Agata; Furmanek, Miroslaw; Veselka, Barbara; Veleminsky, Petr; Vercellotti, Giuseppe; Wahl, Joachim; Zarina, Gunita; Longhi, Cristina; Kolar, Jan; Garrido-Pena, Rafael; Flores-Fernandez, Raul; Herrero-Corral, Anna M.; Simalcsik, Angela; Muller, Werner; Sheridan, Alison; Miliauskiene, Zydrune; Jankauskas, Rimantas; Moiseyev, Vyacheslav; Kohler, Kitti; Kiraly, Agnes; Gamarra, Beatriz; Cheronet, Olivia; Szeverenyi, Vajk; Kiss, Viktoria; Szeniczey, Tamas; Kiss, Krisztian; Zoffmann, Zsuzsanna; Koos, Judit; Hellebrandt, Magdolna; Maier, Robert; Domboroczki, Laszlo; Virag, Cristian; Novak, Mario; Reich, David; Hajdu, Tamas; Von Cramon-Taubadel, Noreen; Pinhasi, Ron; Perry, George.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 15, e2106743119, 12.04.2022, p. 1-12.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - An integrative skeletal paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers

AU - Marciniak, Stephanie

AU - Bergey, Christina

AU - Silva, Anna Maria

AU - Haluszko, Agata

AU - Furmanek, Miroslaw

AU - Veselka, Barbara

AU - Veleminsky, Petr

AU - Vercellotti, Giuseppe

AU - Wahl, Joachim

AU - Zarina, Gunita

AU - Longhi, Cristina

AU - Kolar, Jan

AU - Garrido-Pena, Rafael

AU - Flores-Fernandez, Raul

AU - Herrero-Corral, Anna M.

AU - Simalcsik, Angela

AU - Muller, Werner

AU - Sheridan, Alison

AU - Miliauskiene, Zydrune

AU - Jankauskas, Rimantas

AU - Moiseyev, Vyacheslav

AU - Kohler, Kitti

AU - Kiraly, Agnes

AU - Gamarra, Beatriz

AU - Cheronet, Olivia

AU - Szeverenyi, Vajk

AU - Kiss, Viktoria

AU - Szeniczey, Tamas

AU - Kiss, Krisztian

AU - Zoffmann, Zsuzsanna

AU - Koos, Judit

AU - Hellebrandt, Magdolna

AU - Maier, Robert

AU - Domboroczki, Laszlo

AU - Virag, Cristian

AU - Novak, Mario

AU - Reich, David

AU - Hajdu, Tamas

AU - Von Cramon-Taubadel, Noreen

AU - Pinhasi, Ron

AU - Perry, George

N1 - Funding Information: ACKNOWLEDGMENTS. We thank the many researchers and skeletal collections curators for their positive responses to us and their interest in this study, even when materials or data were unavailable for inclusion. Components of this work were supported by Wenner-Gren Foundation Grant 222377 (to S.M.), NIH Grant R01-GM115656 (to G.H.P.), and the Harry J. and Elissa M. Sichi Early Career Professorship in Anthropology (to G.H.P.). P.V. was supported by Ministry of Culture of the Czech Republic Grant DKRVO/2019-2023/7.I.d, National Museum, 00023272. J Kolá≤r was supported by Long-Term Development Project RV67985939 of the Institute of Botany of the Czech Academy of Sciences and Czech Science Foundation Grant 19-20970Y. B.G. was supported by Marie Skłodowska-Curie Grant H2020-MSCA-IF-2015 -703373. T.S., K.K., and T.H. were supported by a grant of Hungarian Research, Development and Innovation Office Projects FK128013 and K124326. M.N. was supported by Croatian Science Fund Grant HRZZ IP-2016-06-1450. G.H.P. thanks the DFG Center for Advanced Studies “Words, Bones, Genes, Tools” at the University of T€ubingen for support. Computations for this research were performed on the Pennsylvania State University’s Institute for Computational and Data Sciences’ supercomputing cluster. This content is solely the responsibility of the authors and does not necessarily represent the views of the Institute for Computational and Data Sciences. Funding Information: We thank the many researchers and skeletal collections curators for their positive responses to us and their interest in this study, even when materials or data were unavailable for inclusion. Components of this work were supported by Wenner-Gren Foundation Grant 222377 (to S.M.), NIH Grant R01-GM115656 (to G.H.P.), and the Harry J. and Elissa M. Sichi Early Career Professorship in Anthropology (to G.H.P.). P.V. was supported by Ministry of Culture of the Czech Republic Grant DKRVO/2019-2023/7.I.d, National Museum, 00023272. J Kolar was supported by Long-Term Development Project RV67985939 of the Institute of Botany of the Czech Academy of Sciences and Czech Science Foundation Grant 19-20970Y. B.G. was supported by Marie Skłodowska-Curie Grant H2020-MSCA-IF-2015 -703373. T.S., K.K., and T.H. were supported by a grant of Hungarian Research, Development and Innovation Office Projects FK128013 and K124326. M.N. was supported by Croatian Science Fund Grant HRZZ IP-2016-06-1450. G.H.P. thanks the DFG Center for Advanced Studies “Words, Bones, Genes, Tools” at the University of Tubingen for support. Computations for this research were performed on the Pennsylvania State University's Institute for Computational and Data Sciences' supercomputing cluster. This content is solely the responsibility of the authors and does not necessarily represent the views of the Institute for Computational and Data Sciences. Publisher Copyright: Copyright © 2022 the Author(s). Copyright: Copyright 2022 Elsevier B.V., All rights reserved.

PY - 2022/4/12

Y1 - 2022/4/12

N2 - SignificanceSubsistence shifts from hunting and gathering to agriculture over the last 12,000 y have impacted human culture, biology, and health. Although past human health cannot be assessed directly, adult stature variation and skeletal indicators of nonspecific stress can serve as proxies for health during growth and development. By integrating paleogenomic genotype and osteological stature data on a per-individual basis for 167 prehistoric Europeans, we observe relatively shorter than expected statures among early farmers after correcting for individual genetic contributions to stature. Poorer nutrition and/or increased disease burdens for early agriculturalists may partly underscore this result. Our integrated osteological-genetic model has exciting potential for studies of past human health and expansion into various other contexts.

AB - SignificanceSubsistence shifts from hunting and gathering to agriculture over the last 12,000 y have impacted human culture, biology, and health. Although past human health cannot be assessed directly, adult stature variation and skeletal indicators of nonspecific stress can serve as proxies for health during growth and development. By integrating paleogenomic genotype and osteological stature data on a per-individual basis for 167 prehistoric Europeans, we observe relatively shorter than expected statures among early farmers after correcting for individual genetic contributions to stature. Poorer nutrition and/or increased disease burdens for early agriculturalists may partly underscore this result. Our integrated osteological-genetic model has exciting potential for studies of past human health and expansion into various other contexts.

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U2 - 10.1073/pnas.2106743119

DO - 10.1073/pnas.2106743119

M3 - Article

VL - 119

SP - 1

EP - 12

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 15

M1 - e2106743119

ER -

An integrative skeletal paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers

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IRP18: The Make-Up of the City: A Transdisciplinary Study of Urban Society in the Pre-Modern Low Countries

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An integrative skeletal paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers

Abstract

Bibliographical note

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Fingerprint

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IRP18: The Make-Up of the City: A Transdisciplinary Study of Urban Society in the Pre-Modern Low Countries

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Data from: An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers

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