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Abstract
In positron emission tomography (PET), an accurate quantitative reconstruction of the tracer distribution requires taking into account the attenuation of the photons by the tissues. The spatial distribution of the attenuation coefficient (the attenuation image) is usually estimated by means of a CT scan, extrapolated to the required photon energy of 511 keV, and forward projected to obtain the attenuation sinogram.
We consider applications where this external information about the attenuation is unavailable, or inaccurate due for instance to patient motion between the transmission scan and the emission scan. In such a case the attenuation must be estimated from the emission data only. Previous studies have shown that time-of flight (TOF) data contain significant information on the attenuation. Recently, we gave an accurate characterization of this property by proving that the attenuation sinogram is determined, up to a constant multiplicative factor, by the 2D TOF data and that it can be calculated using an efficient analytic algorithm. The present paper extends this work to 3D TOF PET. I
We consider applications where this external information about the attenuation is unavailable, or inaccurate due for instance to patient motion between the transmission scan and the emission scan. In such a case the attenuation must be estimated from the emission data only. Previous studies have shown that time-of flight (TOF) data contain significant information on the attenuation. Recently, we gave an accurate characterization of this property by proving that the attenuation sinogram is determined, up to a constant multiplicative factor, by the 2D TOF data and that it can be calculated using an efficient analytic algorithm. The present paper extends this work to 3D TOF PET. I
| Original language | English |
|---|---|
| Title of host publication | 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record |
| Publisher | IEEE |
| Pages | 2330-2333 |
| Number of pages | 4 |
| ISBN (Print) | 978-1-4673-2029-0 |
| Publication status | Published - 2012 |
| Event | Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2012 IEEE - Anaheim, United States Duration: 27 Oct 2012 → 3 Nov 2012 |
Conference
| Conference | Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2012 IEEE |
|---|---|
| Abbreviated title | (NSS/MIC) |
| Country/Territory | United States |
| City | Anaheim |
| Period | 27/10/12 → 3/11/12 |
Keywords
- positron emission tomography
Fingerprint
Dive into the research topics of 'Analytic reconstruction of the attenuation from 3D time-of-flight PET data'. Together they form a unique fingerprint.Projects
- 1 Finished
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GOA28: Development of positron emission tomography technologies for cancer diagnosis and new drugs development
Bossuyt, A. (Co-Promotor), Mertens, J. (Co-Promotor), Tavernier, S. (Administrative Promotor), Deconinck, F. (Co-Promotor) & Defrise, M. (Co-Promotor)
1/01/03 → 31/12/07
Project: Fundamental