Anemia and transfusions in geriatric patients: a time for evaluation

Anemia is common in the elderly, especially in very old patients who are often frail and may be
institutionalized. Senescence, the ageing process, puts the elderly at risk of developing anemia
for multiple reasons, but anemia may not be attributed to senescence unless a thorough
diagnostic workup has excluded other etiologies. Nutritional deficiencies are common and need
to be identified and treated appropriately. Inflammatory diseases and renal failure are also
frequent etiological factors and tend to be chronic. Myelodysplastic syndromes increase in
frequency with age and may be difficult to diagnose and only a minority of cases respond to
appropriate treatment. Anemia is associated with poor outcome and symptomatic treatment with
transfusions frequently has to be considered. Red blood cell transfusion has a high therapeutic
index and is likely to be effective only if anemia is symptomatic or particularly severe, as a
consequence, its use has been restricted to this group. Much of the evidence on usage is limited
to younger adults and specific clinical situations. Geriatricians have to deal with a large number of
patients with significant anemia but with an absence of well constructed guidelines for the frail
and the very old. The object of the present article is to raise awareness that anemia in the geriatric
group is multi-factorial and that the patients are more than merely older than those included in
most studies, that the results of ongoing trials should be appropriately interpreted and will be
important in guiding future practice.