Animal models of organic heart valve disease

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12 Citations (Scopus)


Heart valve disease is a frequently encountered pathology, related to high morbidity and mortality rates in
industrialized and developing countries. Animal models are interesting to investigate the causality, but also
underlying mechanisms and potential treatments of human valvular diseases. Recently, animal models of
heart valve disease have been developed, which allow to investigate the pathophysiology, and to follow
the progression and the potential regression of disease with therapeutics over time. The present review
provides an overview of animal models of primary, organic heart valve disease: myxoid age-related, infectious,
drug-induced, degenerative calcified, and mechanically induced valvular heart disease.
Original languageEnglish
Pages (from-to)398-409
Number of pages12
JournalInternational Journal of Cardiology
Issue number3
Publication statusPublished - 25 May 2013


  • Aging
  • Calcification
  • Drugs
  • Endocarditis
  • Heart valves
  • Small animals


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