Anti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia?

Research output: Contribution to journalArticlepeer-review


We describe an unusual case of severe and chronic insomnia that proved to be eminently treatable.
Initially presumed to be of primary psychiatric/toxicological origin, certain clinical and paraclinical
clues led us to the diagnosis of NMDA-receptor encephalitis, an immune-mediated disease of the
brain. Our patient responded dramatically to immunotherapy, effectively regaining normal sleep habits
and significantly improving his general and mental health after 25 years of insomnia and drug abuse.
Immune-mediated encephalopathies should be considered in the differential diagnosis of severe sleep
disorders that present with additional neurological signs and symptoms, even when chronic.
Original languageEnglish
Pages (from-to)296-298
Number of pages4
JournalSleep Science
Issue number3
Early online date30 Nov 2020
Publication statusPublished - 2021


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