Antidiabetic, dermatoprotective, antioxidant and chemical functionalities in Zizyphus lotus leaves and fruits.

Ilias Marmouzi; Mourad Kharbach; Meryem El Jemli; Abdelhakim Bouyahya; Yahia Cherrah; Abdelaziz Bouklouze; Yvan Vander Heyden; My El Abbes Faouzi

doi:10.1016/j.indcrop.2019.02.007

Antidiabetic, dermatoprotective, antioxidant and chemical functionalities in Zizyphus lotus leaves and fruits.

Ilias Marmouzi, Mourad Kharbach, Meryem El Jemli, Abdelhakim Bouyahya, Yahia Cherrah, Abdelaziz Bouklouze, Yvan Vander Heyden, My El Abbes Faouzi

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Abstract

Medicinal plants provide important sources of new chemical substances with potential therapeutic effects. They have been used in traditional medicine for the treatment of several diseases. The present study investigated the antidiabetic (anti-amylase and anti-glucosidase) and dermatoprotective (anti-tyrosinase) activities of Zizyphus lotus (Rhamnaceae) leaves and fruits. This plant is known for several medicinal applications; the phenolic profile of aqueous extracts of Z. lotus was also developed using HPLC-DAD-QTOF-MS analysis. The chemical analysis resulted in the identification and quantification of twenty phenolic compounds in the fruits and/or leaves.
Zizyphus lotus was highly dosed in gallic acid with 2715 mg/kg in leaves and 15,640 mg/kg in fruits. Z. lotus leaves and fruits, demonstrated inhibitory effects against α-amylase (IC50: 20.40–31.91 μg/mL), and α-glucosidase
(IC50: 8.66–27.95 μg/mL). In tyrosinase inhibition, the fruits exhibited a higher effect (70.23 μg/mL) than the leaves. Furthermore, the extracts did show interesting antioxidant activity; thus Z. lotus constitutes a promising
traditional medicine and this study contributed to identify some functional compounds responsible for its bioactivity.

Original language	English
Pages (from-to)	134-139
Number of pages	6
Journal	Industrial Crops and Products
Volume	132
DOIs	https://doi.org/10.1016/j.indcrop.2019.02.007
Publication status	Published - Jun 2019

Keywords

Glucosidase
Leaves, fruits
Phenolic compounds
Tyrosinase
Zizyphus lotus

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10.1016/j.indcrop.2019.02.007

Author copy ZL.Marmouzi. et al. 2019Accepted author manuscript, 900 KBLicence: CC BY

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@article{4c756776ad86412cb135758811f3c22a,

title = "Antidiabetic, dermatoprotective, antioxidant and chemical functionalities in Zizyphus lotus leaves and fruits.",

abstract = "Medicinal plants provide important sources of new chemical substances with potential therapeutic effects. They have been used in traditional medicine for the treatment of several diseases. The present study investigated the antidiabetic (anti-amylase and anti-glucosidase) and dermatoprotective (anti-tyrosinase) activities of Zizyphus lotus (Rhamnaceae) leaves and fruits. This plant is known for several medicinal applications; the phenolic profile of aqueous extracts of Z. lotus was also developed using HPLC-DAD-QTOF-MS analysis. The chemical analysis resulted in the identification and quantification of twenty phenolic compounds in the fruits and/or leaves.Zizyphus lotus was highly dosed in gallic acid with 2715 mg/kg in leaves and 15,640 mg/kg in fruits. Z. lotus leaves and fruits, demonstrated inhibitory effects against α-amylase (IC50: 20.40–31.91 μg/mL), and α-glucosidase(IC50: 8.66–27.95 μg/mL). In tyrosinase inhibition, the fruits exhibited a higher effect (70.23 μg/mL) than the leaves. Furthermore, the extracts did show interesting antioxidant activity; thus Z. lotus constitutes a promisingtraditional medicine and this study contributed to identify some functional compounds responsible for its bioactivity.",

keywords = "Glucosidase, Leaves, fruits, Phenolic compounds, Tyrosinase, Zizyphus lotus",

author = "Ilias Marmouzi and Mourad Kharbach and {El Jemli}, Meryem and Abdelhakim Bouyahya and Yahia Cherrah and Abdelaziz Bouklouze and {Vander Heyden}, Yvan and Faouzi, {My El Abbes}",

year = "2019",

month = jun,

doi = "10.1016/j.indcrop.2019.02.007",

language = "English",

volume = "132",

pages = "134--139",

journal = "Industrial Crops and Products",

issn = "0926-6690",

publisher = "Elsevier",

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T1 - Antidiabetic, dermatoprotective, antioxidant and chemical functionalities in Zizyphus lotus leaves and fruits.

AU - Marmouzi, Ilias

AU - Kharbach, Mourad

AU - El Jemli, Meryem

AU - Bouyahya, Abdelhakim

AU - Cherrah, Yahia

AU - Bouklouze, Abdelaziz

AU - Vander Heyden, Yvan

AU - Faouzi, My El Abbes

PY - 2019/6

Y1 - 2019/6

N2 - Medicinal plants provide important sources of new chemical substances with potential therapeutic effects. They have been used in traditional medicine for the treatment of several diseases. The present study investigated the antidiabetic (anti-amylase and anti-glucosidase) and dermatoprotective (anti-tyrosinase) activities of Zizyphus lotus (Rhamnaceae) leaves and fruits. This plant is known for several medicinal applications; the phenolic profile of aqueous extracts of Z. lotus was also developed using HPLC-DAD-QTOF-MS analysis. The chemical analysis resulted in the identification and quantification of twenty phenolic compounds in the fruits and/or leaves.Zizyphus lotus was highly dosed in gallic acid with 2715 mg/kg in leaves and 15,640 mg/kg in fruits. Z. lotus leaves and fruits, demonstrated inhibitory effects against α-amylase (IC50: 20.40–31.91 μg/mL), and α-glucosidase(IC50: 8.66–27.95 μg/mL). In tyrosinase inhibition, the fruits exhibited a higher effect (70.23 μg/mL) than the leaves. Furthermore, the extracts did show interesting antioxidant activity; thus Z. lotus constitutes a promisingtraditional medicine and this study contributed to identify some functional compounds responsible for its bioactivity.

AB - Medicinal plants provide important sources of new chemical substances with potential therapeutic effects. They have been used in traditional medicine for the treatment of several diseases. The present study investigated the antidiabetic (anti-amylase and anti-glucosidase) and dermatoprotective (anti-tyrosinase) activities of Zizyphus lotus (Rhamnaceae) leaves and fruits. This plant is known for several medicinal applications; the phenolic profile of aqueous extracts of Z. lotus was also developed using HPLC-DAD-QTOF-MS analysis. The chemical analysis resulted in the identification and quantification of twenty phenolic compounds in the fruits and/or leaves.Zizyphus lotus was highly dosed in gallic acid with 2715 mg/kg in leaves and 15,640 mg/kg in fruits. Z. lotus leaves and fruits, demonstrated inhibitory effects against α-amylase (IC50: 20.40–31.91 μg/mL), and α-glucosidase(IC50: 8.66–27.95 μg/mL). In tyrosinase inhibition, the fruits exhibited a higher effect (70.23 μg/mL) than the leaves. Furthermore, the extracts did show interesting antioxidant activity; thus Z. lotus constitutes a promisingtraditional medicine and this study contributed to identify some functional compounds responsible for its bioactivity.

KW - Glucosidase

KW - Leaves, fruits

KW - Phenolic compounds

KW - Tyrosinase

KW - Zizyphus lotus

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DO - 10.1016/j.indcrop.2019.02.007

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SN - 0926-6690

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EP - 139

JO - Industrial Crops and Products

JF - Industrial Crops and Products

ER -

Antidiabetic, dermatoprotective, antioxidant and chemical functionalities in Zizyphus lotus leaves and fruits.

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Keywords

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