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Abstract
The invention generally relates to the field of radiochemistry. In particular, the present invention provides an asparaginyl peptide ligase (PAL)-mediated method of producing site- specifically radiolabeled single-domain antibody (sdAb) tracers, optionally in the presence of a glutaminyl cyclase (QC). The radiolabelled sdAb tracers prepared by the method of the present invention provide enhanced characteristics and are suitable for use in diagnosis, in surgery, in treatment, in therapy monitoring, and as an imaging agent.
| Original language | English |
|---|---|
| Patent number | EP4673554A1 |
| Publication status | Published - 2026 |
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FWOAL1154: VYPER — Viola Yedoensis Peptide asparagine ligase (VyPAL) Enzyme-mediated generation of Radiotheranostics
Devoogdt, N. (Administrative Promotor), Caveliers, V. (CoI (Co-Promotor)) & Bridoux, J. (CoI (Co-Promotor))
1/01/25 → 31/12/28
Project: Fundamental
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FWOTM1157: Development of automated enzyme-mediated bioconjugations as a technology to produce smallprotein-based radiopharmaceu
Bridoux, J. (Mandate) & Devoogdt, N. (Administrative Promotor)
1/10/23 → 30/09/26
Project: Fundamental
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IOF3009: GEAR: Integrating a multimodal approach to address current challenges in immunotherapy (INTEGRAL)
Lahoutte, T. (Administrative Promotor), Devoogdt, N. (Co-Promotor), Keyaerts, M. (Co-Promotor), Van Ginderachter, J. (Co-Promotor), Laoui, D. (Co-Promotor), Raes, G. (Co-Promotor), Breckpot, K. (Co-Promotor), Goyvaerts, C. (Co-Promotor), Raes, G. (Mandate), Bridoux, J. (Mandate) & Baudhuin, H. V. (Mandate)
1/01/20 → 30/06/25
Project: Applied
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