Assessment of Retinal Pigment Epithelium Alterations and Chorioretinal Vascular Network Analyses in Patients under Treatment with BRAF/MEK Inhibitor for Different Malignancies: A Pilot Study

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Abstract

In the last two decades, an increasing number of so-called molecular-targeted therapies have become available for the treatment of patients with advanced malignancies. These drugs have included inhibitors of proteins in the MAPK pathway, such as BRAF and MEK inhibitors, which are characterized by a distinct toxicity profile. The eye is particularly susceptible to adverse effects due to MEK inhibitors, and the term MEKAR (MEK-inhibitor-associated retinopathy) indicates the presence of subretinal fluid, mimicking central serous chorioretinopathy (CSC). The pathogenesis of the retinal alterations related to MAPK pathway inhibitors is still unclear, and questions are still open. The present study aims to assess the presence of retinal pigment epithelium alterations as predictive parameters for retinal toxicity, analyzing, at the same time, the chorioretinal vascular network in patients undergoing BRAF/MEK inhibitor treatment for different malignancies.

Original languageEnglish
Article number1214
Number of pages10
JournalJournal of clinical medicine
Volume12
Issue number3
DOIs
Publication statusPublished - 3 Feb 2023

Bibliographical note

Funding Information:
This research was funded by Bayer, grant number T202101077/001542.

Publisher Copyright:
© 2023 by the authors.

Copyright:
Copyright 2023 Elsevier B.V., All rights reserved.

Keywords

  • BRAF/MEK inhibitor adverse effect
  • MEK-inhibitor-associated retinopathy
  • central serous chorioretinopathy

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