Association of IL-2RA/CD25 with type 1 diabetes in the Belgian population

Belgian Diabetes Registry

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Abstract

Our goals were to study the proposed association of IL-2RA /CD25 with type 1 diabetes in the Belgian population over a broad age range, and to explore possible correlations with disease phenotypes, immune markers, HLA-DQ, INS, and PTPN22. Patients (n = 1954), healthy controls (n = 2082), and families (n = 420) were genotyped for IL-2RA/CD25 rs41295061(C>A), HLA-DQ, INS-VNTR and PTPN22. IL-2RA/CD25 was associated with type 1 diabetes (χ(2) = 26.8, p < 0.001 for alleles and χ(2) = 29.6, p < 0.001 for genotypes). The C allele (odds ratios [OR] = 1.59) and C/C genotype (OR = 1.56) were identified as susceptibility variants, whereas the A allele (OR = 0.63), A/A genotype (OR = 0.14), and A/C genotype (OR = 0.69) as protective variants. IL-2RA/CD25 is associated with both early-onset and late-onset type 1 diabetes, but with a larger effect size in early-onset disease. There was a nonsignificant tendency toward transmission distortion (p = 0.063). Except a tendency toward younger age at onset in carriers of the C/C genotype, no correlations with disease phenotype, immune markers, HLA-DQ, INS and PTPN22 were observed. Also, the frequency of the susceptible genotype was higher in early-onset compared with late-onset TID patients (p = 0.015). In conclusion, IL-2RA/CD25 is associated with type 1 diabetes in the Belgian population, independently of disease phenotype and other biologic markers.

Original languageEnglish
Pages (from-to)1233-1237
Number of pages5
JournalHuman Immunology
Volume71
Issue number12
DOIs
Publication statusPublished - Dec 2010

Bibliographical note

Copyright © 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

Keywords

  • Adolescent
  • Adult
  • Age of Onset
  • Autoantibodies/blood
  • Belgium/epidemiology
  • Child
  • Diabetes Mellitus, Type 1/epidemiology
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • HLA-DQ Antigens/genetics
  • Humans
  • Interleukin-2 Receptor alpha Subunit/genetics
  • Male
  • Phenotype
  • Polymorphism, Genetic
  • Protein Tyrosine Phosphatase, Non-Receptor Type 22/genetics
  • Young Adult

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