Asthma endophenotypes and polymorphisms in the histamine receptor HRH4 gene

Tünde Simon, Agnes F Semsei, Ildikó Ungvári, Eva Hadadi, Viktor Virág, Adrienne Nagy, Mónika S Vangor, Valéria László, Csaba Szalai, András Falus

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


BACKGROUND: Histamine as an inflammatory mediator plays an important role in chronic allergic and asthmatic conditions. However, the role of genetic polymorphisms of the histamine receptor HRH4 (histamine receptor H4) gene in asthma susceptibility and endophenotypes has not been studied yet. Our aim was to investigate the possible association between single nucleotide polymorphisms (SNPs) in the HRH4 gene and asthma or some endophenotypes of asthma.

METHODS: Twenty-one SNPs of the HRH4 gene were genotyped in 313 asthmatic patients and 360 controls using Sequenom® iPLEX® Gold Genotyping Technology.

RESULTS: Genotype distribution of three HRH4 SNPs, namely rs17187619 [p = 0.002; odds ratio, OR (95% confidence interval, CI) = 2.4 (4.1-1.4)], rs527790 [p = 0.0002; OR (95% CI) = 3.3 (6.1-1.8)] and rs487202 [p = 0.00007; OR (95% CI) = 3.5 (6.6-1.9)] differed significantly between patients with or without infection-induced asthma. Haplotypes, which included the rs4800573-rs527790 CC allele combination, were found to be associated with infection-induced asthma [p = 0.0009, OR (95% CI) = 0.5 (0.4-0.8)]. The rs487202-rs574913 CA haplotype was more frequent among patients with infection-induced asthma [p = 0.0006, OR (95% CI) = 1.9 (1.3-2.6)]. None of the SNPs contributed directly to the risk of asthma.

CONCLUSIONS: Our results suggest that genetic variation in the HRH4 gene might influence the pathogenesis of infection-induced asthma.

Original languageEnglish
Pages (from-to)109-20
Number of pages12
JournalInternational Archives of Allergy and Immunology
Issue number2
Publication statusPublished - 2012
Externally publishedYes

Bibliographical note

Copyright © 2012 S. Karger AG, Basel.


  • Adolescent
  • Asthma/etiology
  • Base Sequence
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Endophenotypes
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Haplotypes
  • Humans
  • Infections/complications
  • Linkage Disequilibrium
  • Male
  • Polymorphism, Single Nucleotide
  • Receptors, G-Protein-Coupled/genetics
  • Receptors, Histamine/genetics
  • Receptors, Histamine H4
  • Risk Factors
  • Young Adult


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